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Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases
Recent research progress on the “second generation” type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R(1)–C–R(2) scaf...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Singapore
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456412/ https://www.ncbi.nlm.nih.gov/pubmed/32500363 http://dx.doi.org/10.1007/s11418-020-01414-9 |
Sumario: | Recent research progress on the “second generation” type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R(1)–C–R(2) scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for future drug development. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-020-01414-9) contains supplementary material, which is available to authorized users. |
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