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The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis

BACKGROUND: This systematic review and meta-analysis assessed the role of teriparatide in improving hip fracture healing and function to provide a clinical guide. METHODS: The systematic literature review identified randomized controlled trials (RCTs) and controlled studies evaluating teriparatide f...

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Autores principales: Han, Shuang, Wen, Shi-Ming, Zhao, Qin-Peng, Huang, Hai, Wang, Hu, Cong, Yu-Xuan, Shang, Kun, Ke, Chao, Zhuang, Yan, Zhang, Bin-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456478/
https://www.ncbi.nlm.nih.gov/pubmed/32904518
http://dx.doi.org/10.1155/2020/5914502
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author Han, Shuang
Wen, Shi-Ming
Zhao, Qin-Peng
Huang, Hai
Wang, Hu
Cong, Yu-Xuan
Shang, Kun
Ke, Chao
Zhuang, Yan
Zhang, Bin-Fei
author_facet Han, Shuang
Wen, Shi-Ming
Zhao, Qin-Peng
Huang, Hai
Wang, Hu
Cong, Yu-Xuan
Shang, Kun
Ke, Chao
Zhuang, Yan
Zhang, Bin-Fei
author_sort Han, Shuang
collection PubMed
description BACKGROUND: This systematic review and meta-analysis assessed the role of teriparatide in improving hip fracture healing and function to provide a clinical guide. METHODS: The systematic literature review identified randomized controlled trials (RCTs) and controlled studies evaluating teriparatide for elderly hip fractures. A meta-analysis was performed using RevMan version 5.3. RESULTS: This study included two RCTs and four retrospective studies comprising 607 patients, with 269 and 338 patients in the teriparatide and control groups, respectively. The quality of these six studies was moderate. Compared to the control group, teriparatide reduced the time to union (weighted mean difference (WMD) = −1.95; 95% confidence interval (CI): -3.23–-0.68; P = 0.003) but did not improve the rate of fracture union at 3 months (odds ratio (OR) = 1.46; 95% CI: 0.50–4.24; P = 0.49) or 6 months (OR = 0.89; 95% CI: 0.44–1.81; P = 0.75). In addition, teriparatide did not decrease the complications, need for reoperation, mortality, rate of deformity after fracture healing, and subsequent fracture or improve hip function. CONCLUSIONS: The current limited evidence did not support that teriparatide improves fracture healing in hip fractures, due to study heterogeneity and various sources of biases. Further high-quality, large-sample trials are needed. This trial is registered with PROSPERO with registration number CRD42020152205.
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spelling pubmed-74564782020-09-03 The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis Han, Shuang Wen, Shi-Ming Zhao, Qin-Peng Huang, Hai Wang, Hu Cong, Yu-Xuan Shang, Kun Ke, Chao Zhuang, Yan Zhang, Bin-Fei Biomed Res Int Review Article BACKGROUND: This systematic review and meta-analysis assessed the role of teriparatide in improving hip fracture healing and function to provide a clinical guide. METHODS: The systematic literature review identified randomized controlled trials (RCTs) and controlled studies evaluating teriparatide for elderly hip fractures. A meta-analysis was performed using RevMan version 5.3. RESULTS: This study included two RCTs and four retrospective studies comprising 607 patients, with 269 and 338 patients in the teriparatide and control groups, respectively. The quality of these six studies was moderate. Compared to the control group, teriparatide reduced the time to union (weighted mean difference (WMD) = −1.95; 95% confidence interval (CI): -3.23–-0.68; P = 0.003) but did not improve the rate of fracture union at 3 months (odds ratio (OR) = 1.46; 95% CI: 0.50–4.24; P = 0.49) or 6 months (OR = 0.89; 95% CI: 0.44–1.81; P = 0.75). In addition, teriparatide did not decrease the complications, need for reoperation, mortality, rate of deformity after fracture healing, and subsequent fracture or improve hip function. CONCLUSIONS: The current limited evidence did not support that teriparatide improves fracture healing in hip fractures, due to study heterogeneity and various sources of biases. Further high-quality, large-sample trials are needed. This trial is registered with PROSPERO with registration number CRD42020152205. Hindawi 2020-08-20 /pmc/articles/PMC7456478/ /pubmed/32904518 http://dx.doi.org/10.1155/2020/5914502 Text en Copyright © 2020 Shuang Han et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Han, Shuang
Wen, Shi-Ming
Zhao, Qin-Peng
Huang, Hai
Wang, Hu
Cong, Yu-Xuan
Shang, Kun
Ke, Chao
Zhuang, Yan
Zhang, Bin-Fei
The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title_full The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title_fullStr The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title_full_unstemmed The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title_short The Efficacy of Teriparatide in Improving Fracture Healing in Hip Fractures: A Systematic Review and Meta-Analysis
title_sort efficacy of teriparatide in improving fracture healing in hip fractures: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456478/
https://www.ncbi.nlm.nih.gov/pubmed/32904518
http://dx.doi.org/10.1155/2020/5914502
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