Cargando…
A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy
Sarcomatoid melanoma is an extremely rare pattern of malignant melanoma, and only few cases have been described throughout the literature. We herein report a case of a patient with newly diagnosed, metastatic giant sarcomatoid melanoma of the arm. The patient underwent surgical removal of the huge m...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456614/ https://www.ncbi.nlm.nih.gov/pubmed/32922664 http://dx.doi.org/10.18632/oncotarget.27701 |
_version_ | 1783575829911961600 |
---|---|
author | Torresetti, Matteo Brancorsini, Donatella Morgese, Francesca Cognigni, Valeria Scalise, Alessandro Berardi, Rossana Di Benedetto, Giovanni |
author_facet | Torresetti, Matteo Brancorsini, Donatella Morgese, Francesca Cognigni, Valeria Scalise, Alessandro Berardi, Rossana Di Benedetto, Giovanni |
author_sort | Torresetti, Matteo |
collection | PubMed |
description | Sarcomatoid melanoma is an extremely rare pattern of malignant melanoma, and only few cases have been described throughout the literature. We herein report a case of a patient with newly diagnosed, metastatic giant sarcomatoid melanoma of the arm. The patient underwent surgical removal of the huge mass, and NGS sequencing demonstrated BRAF V600E mutation. In view of histological, immunohistochemical and molecular findings, a combined BRAF/MEK inhibitor (BRAF/MEK-i) therapy was prescribed as first line treatment. A complete response (over one year) to targeted therapy was obtained, and no adverse events have been reported. The patient maintained a full range of shoulder and elbow movements, and she is able to live independently and resume her daily activities. We therefore recommend that all patients with undifferentiated melanomas, sarcomatoid cutaneous malignancies or other mesenchymal tumours, should undergo BRAFV600E mutation testing. |
format | Online Article Text |
id | pubmed-7456614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-74566142020-09-11 A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy Torresetti, Matteo Brancorsini, Donatella Morgese, Francesca Cognigni, Valeria Scalise, Alessandro Berardi, Rossana Di Benedetto, Giovanni Oncotarget Case Report Sarcomatoid melanoma is an extremely rare pattern of malignant melanoma, and only few cases have been described throughout the literature. We herein report a case of a patient with newly diagnosed, metastatic giant sarcomatoid melanoma of the arm. The patient underwent surgical removal of the huge mass, and NGS sequencing demonstrated BRAF V600E mutation. In view of histological, immunohistochemical and molecular findings, a combined BRAF/MEK inhibitor (BRAF/MEK-i) therapy was prescribed as first line treatment. A complete response (over one year) to targeted therapy was obtained, and no adverse events have been reported. The patient maintained a full range of shoulder and elbow movements, and she is able to live independently and resume her daily activities. We therefore recommend that all patients with undifferentiated melanomas, sarcomatoid cutaneous malignancies or other mesenchymal tumours, should undergo BRAFV600E mutation testing. Impact Journals LLC 2020-08-25 /pmc/articles/PMC7456614/ /pubmed/32922664 http://dx.doi.org/10.18632/oncotarget.27701 Text en http://creativecommons.org/licenses/by/3.0/ Copyright: Torresetti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Torresetti, Matteo Brancorsini, Donatella Morgese, Francesca Cognigni, Valeria Scalise, Alessandro Berardi, Rossana Di Benedetto, Giovanni A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title | A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title_full | A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title_fullStr | A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title_full_unstemmed | A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title_short | A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy |
title_sort | case report of metastatic giant sarcomatoid melanoma with braf v600e mutation: a complete response to targeted therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456614/ https://www.ncbi.nlm.nih.gov/pubmed/32922664 http://dx.doi.org/10.18632/oncotarget.27701 |
work_keys_str_mv | AT torresettimatteo acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT brancorsinidonatella acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT morgesefrancesca acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT cognignivaleria acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT scalisealessandro acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT berardirossana acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT dibenedettogiovanni acasereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT torresettimatteo casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT brancorsinidonatella casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT morgesefrancesca casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT cognignivaleria casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT scalisealessandro casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT berardirossana casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy AT dibenedettogiovanni casereportofmetastaticgiantsarcomatoidmelanomawithbrafv600emutationacompleteresponsetotargetedtherapy |