Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations

Background Prevalence and mortality rates during the coronavirus disease 2019 (COVID-19) pandemic have varied widely across nations. This phenomenon may be partly due to regional variations in health-related behaviours, some of which may be influenced by health anxiety. A functional polymorphism of the catechol O-methyltransferase (COMT) gene, designated rs4680 or Val(158)Met, has been associated with anxiety-related behaviours and the so-called "worrier" phenotype. Methods In this exploratory study, an analysis of the correlation between the frequencies of the Met allele of the COMT gene across 28 countries, obtained from the public domain Allele Frequency Database (ALFRED), and the COVID-19 prevalence and mortality rates in these countries, obtained from the Johns Hopkins Medical University web-based dashboard, was carried out while controlling for population size and median age in each country. Results Allele frequencies varied widely across populations. Met allele frequency was positively correlated with COVID-19 prevalence (ρ = 0.527, p = 0.004) and mortality rate (ρ = 0.542, p = 0.003) across nations. However, this correlation was no longer significant after controlling for confounders. Conclusions These preliminary results suggest that there may be a relationship between the COMT Val(158)Met or rs4680 functional polymorphism and the impact of COVID-19 across nations, which could plausibly be mediated by maladaptive anxiety-related behaviours.