Inter-compound and Intra-compound Global Sensitivity Analysis of a Physiological Model for Pulmonary Absorption of Inhaled Compounds

In recent years, global sensitivity analysis (GSA) has gained interest in physiologically based pharmacokinetics (PBPK) modelling and simulation from pharmaceutical industry, regulatory authorities, and academia. With the case study of an in-house PBPK model for inhaled compounds in rats, the aim of...

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Detalles Bibliográficos
Autores principales: Melillo, Nicola, Grandoni, Silvia, Cesari, Nicola, Brogin, Giandomenico, Puccini, Paola, Magni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456635/
https://www.ncbi.nlm.nih.gov/pubmed/32862303
http://dx.doi.org/10.1208/s12248-020-00499-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456635/
https://www.ncbi.nlm.nih.gov/pubmed/32862303
http://dx.doi.org/10.1208/s12248-020-00499-0

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