The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

During its clinical development fialuridine caused liver toxicity and the death of five patients. This case remains relevant due to the continued development of mechanistically-related compounds against a back-drop of simple in vitro models which remain limited for the preclinical detection of such...

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Detalles Bibliográficos
Autores principales: Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456776/
https://www.ncbi.nlm.nih.gov/pubmed/32730777
http://dx.doi.org/10.1016/j.taap.2020.115163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456776/
https://www.ncbi.nlm.nih.gov/pubmed/32730777
http://dx.doi.org/10.1016/j.taap.2020.115163

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