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The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to en...

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Autores principales: Rezende, Nathália Saffioti, Swinton, Paul, de Oliveira, Luana Farias, da Silva, Rafael Pires, da Eira Silva, Vinicius, Nemezio, Kleiner, Yamaguchi, Guilherme, Artioli, Guilherme Giannini, Gualano, Bruno, Saunders, Bryan, Dolan, Eimear
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456894/
https://www.ncbi.nlm.nih.gov/pubmed/32922303
http://dx.doi.org/10.3389/fphys.2020.00913
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author Rezende, Nathália Saffioti
Swinton, Paul
de Oliveira, Luana Farias
da Silva, Rafael Pires
da Eira Silva, Vinicius
Nemezio, Kleiner
Yamaguchi, Guilherme
Artioli, Guilherme Giannini
Gualano, Bruno
Saunders, Bryan
Dolan, Eimear
author_facet Rezende, Nathália Saffioti
Swinton, Paul
de Oliveira, Luana Farias
da Silva, Rafael Pires
da Eira Silva, Vinicius
Nemezio, Kleiner
Yamaguchi, Guilherme
Artioli, Guilherme Giannini
Gualano, Bruno
Saunders, Bryan
Dolan, Eimear
author_sort Rezende, Nathália Saffioti
collection PubMed
description Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplementation strategy. To address these questions, we conducted a systematic review with Bayesian-based meta-analysis of all published aggregate data using a dose response (Emax) model. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline MCarn, and analysis method used) on the primary outcome. The protocol was designed according to PRISMA guidelines and a three-step screening strategy was undertaken to identify studies that measured the MCarn response to BA supplementation. Additionally, we conducted an original analysis of all available individual data on the MCarn response to BA supplementation from studies conducted within our lab (n = 99). The Emax model indicated that human skeletal muscle has large capacity for non-linear MCarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appeared to influence subsequent response to supplementation. Analysis of individual data indicated that MCarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response [95%CrI: 96.2–100]).
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spelling pubmed-74568942020-09-11 The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis Rezende, Nathália Saffioti Swinton, Paul de Oliveira, Luana Farias da Silva, Rafael Pires da Eira Silva, Vinicius Nemezio, Kleiner Yamaguchi, Guilherme Artioli, Guilherme Giannini Gualano, Bruno Saunders, Bryan Dolan, Eimear Front Physiol Physiology Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplementation strategy. To address these questions, we conducted a systematic review with Bayesian-based meta-analysis of all published aggregate data using a dose response (Emax) model. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline MCarn, and analysis method used) on the primary outcome. The protocol was designed according to PRISMA guidelines and a three-step screening strategy was undertaken to identify studies that measured the MCarn response to BA supplementation. Additionally, we conducted an original analysis of all available individual data on the MCarn response to BA supplementation from studies conducted within our lab (n = 99). The Emax model indicated that human skeletal muscle has large capacity for non-linear MCarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appeared to influence subsequent response to supplementation. Analysis of individual data indicated that MCarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response [95%CrI: 96.2–100]). Frontiers Media S.A. 2020-08-14 /pmc/articles/PMC7456894/ /pubmed/32922303 http://dx.doi.org/10.3389/fphys.2020.00913 Text en Copyright © 2020 Rezende, Swinton, de Oliveira, da Silva, da Eira Silva, Nemezio, Yamaguchi, Artioli, Gualano, Saunders and Dolan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rezende, Nathália Saffioti
Swinton, Paul
de Oliveira, Luana Farias
da Silva, Rafael Pires
da Eira Silva, Vinicius
Nemezio, Kleiner
Yamaguchi, Guilherme
Artioli, Guilherme Giannini
Gualano, Bruno
Saunders, Bryan
Dolan, Eimear
The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title_full The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title_fullStr The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title_full_unstemmed The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title_short The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
title_sort muscle carnosine response to beta-alanine supplementation: a systematic review with bayesian individual and aggregate data e-max model and meta-analysis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456894/
https://www.ncbi.nlm.nih.gov/pubmed/32922303
http://dx.doi.org/10.3389/fphys.2020.00913
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