Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents

BACKGROUND: Concomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated with anti-TNF agents. METHODS: Jurkat T cells stabl...

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Detalles Bibliográficos
Autores principales: Wang, Qiaolei, Oryoji, Daisuke, Mitoma, Hiroki, Kimoto, Yasutaka, Koyanagi, Masamichi, Yokoyama, Kana, Ayano, Masahiro, Akahoshi, Mitsuteru, Arinobu, Yojiro, Niiro, Hiroaki, Akashi, Koichi, Horiuchi, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456895/
https://www.ncbi.nlm.nih.gov/pubmed/32922407
http://dx.doi.org/10.3389/fimmu.2020.02042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456895/
https://www.ncbi.nlm.nih.gov/pubmed/32922407
http://dx.doi.org/10.3389/fimmu.2020.02042

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