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Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagn...

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Autores principales: Zhai, ChuanNan, Li, Rui, Hou, Kai, Chen, JingYi, Alzogool, Mohammad, Hu, YueCheng, Zhang, JingXia, Zhang, YingYi, Wang, Le, Zhang, Rui, Cong, HongLiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456928/
https://www.ncbi.nlm.nih.gov/pubmed/32922300
http://dx.doi.org/10.3389/fphys.2020.00691
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author Zhai, ChuanNan
Li, Rui
Hou, Kai
Chen, JingYi
Alzogool, Mohammad
Hu, YueCheng
Zhang, JingXia
Zhang, YingYi
Wang, Le
Zhang, Rui
Cong, HongLiang
author_facet Zhai, ChuanNan
Li, Rui
Hou, Kai
Chen, JingYi
Alzogool, Mohammad
Hu, YueCheng
Zhang, JingXia
Zhang, YingYi
Wang, Le
Zhang, Rui
Cong, HongLiang
author_sort Zhai, ChuanNan
collection PubMed
description Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from the last ten years. Methods: MEDLINE, the Cochrane Central database, and EMBASE were searched between January 2010 and December 2019. Studies that assessed the diagnostic accuracy of circulating microRNAs in AMI were chosen. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve (AUC) were used to assess the test performance of miRNAs. Results: A total of 58 studies that included 8,206 participants assessed the diagnostic accuracy of circulating miRNAs in AMI. The main results of the meta-analyses are as follows: (1) Total miRNAs: the overall pooled sensitivity and specificity were 0.82 (95% CI: 0.79–0.85) and 0.87 (95% CI: 0.84–0.90), respectively. The AUC value was 0.91 (95% CI: 0.88–0.93) in the overall summary receiver operator characteristic (SROC) curve. (2) The panel of two miRNAs: sensitivity: 0.88 (95% CI: 0.77–0.94), specificity: 0.84 (95% CI: 0.72–0.91), AUC: 0.92 (95% CI: 0.90–0.94). (3) The panel of three miRNAs: sensitivity: 0.91 (95% CI: 0.85–0.94), specificity: 0.87 (95% CI: 0.77–0.92), AUC: 0.92 (95% CI: 0.89–0.94). (4) Results by types of miRNAs: miRNA-1: sensitivity: 0.78 (95% CI: 0.71–0.84), specificity: 0.86 (95% CI: 0.77–0.91), AUC: 0.88 (95% CI: 0.85–0.90); miRNA-133a: sensitivity: 0.85 (95% CI: 0.69–0.94), specificity: 0.92 (95% CI: 0.61–0.99), AUC: 0.93 (95% CI: 0.91–0.95); miRNA-208b: sensitivity: 0.80 (95% CI: 0.69–0.88), specificity: 0.96 (95% CI: 0.77–0.99), AUC: 0.91 (95% CI: 0.88–0.93); miRNA-499: sensitivity: 0.85 (95% CI: 0.77–0.91), specificity: 0.95 (95% CI: 0.89–0.98), AUC: 0.96 (95% CI: 0.94–0.97). Conclusion: miRNAs may be used as potential biomarkers for the detection of AMI. For single, stand-alone miRNAs, miRNA-499 may have better diagnostic accuracy compared to other miRNAs. We propose that a panel of multiple miRNAs with high sensitivity and specificity should be tested.
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spelling pubmed-74569282020-09-11 Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis Zhai, ChuanNan Li, Rui Hou, Kai Chen, JingYi Alzogool, Mohammad Hu, YueCheng Zhang, JingXia Zhang, YingYi Wang, Le Zhang, Rui Cong, HongLiang Front Physiol Physiology Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from the last ten years. Methods: MEDLINE, the Cochrane Central database, and EMBASE were searched between January 2010 and December 2019. Studies that assessed the diagnostic accuracy of circulating microRNAs in AMI were chosen. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve (AUC) were used to assess the test performance of miRNAs. Results: A total of 58 studies that included 8,206 participants assessed the diagnostic accuracy of circulating miRNAs in AMI. The main results of the meta-analyses are as follows: (1) Total miRNAs: the overall pooled sensitivity and specificity were 0.82 (95% CI: 0.79–0.85) and 0.87 (95% CI: 0.84–0.90), respectively. The AUC value was 0.91 (95% CI: 0.88–0.93) in the overall summary receiver operator characteristic (SROC) curve. (2) The panel of two miRNAs: sensitivity: 0.88 (95% CI: 0.77–0.94), specificity: 0.84 (95% CI: 0.72–0.91), AUC: 0.92 (95% CI: 0.90–0.94). (3) The panel of three miRNAs: sensitivity: 0.91 (95% CI: 0.85–0.94), specificity: 0.87 (95% CI: 0.77–0.92), AUC: 0.92 (95% CI: 0.89–0.94). (4) Results by types of miRNAs: miRNA-1: sensitivity: 0.78 (95% CI: 0.71–0.84), specificity: 0.86 (95% CI: 0.77–0.91), AUC: 0.88 (95% CI: 0.85–0.90); miRNA-133a: sensitivity: 0.85 (95% CI: 0.69–0.94), specificity: 0.92 (95% CI: 0.61–0.99), AUC: 0.93 (95% CI: 0.91–0.95); miRNA-208b: sensitivity: 0.80 (95% CI: 0.69–0.88), specificity: 0.96 (95% CI: 0.77–0.99), AUC: 0.91 (95% CI: 0.88–0.93); miRNA-499: sensitivity: 0.85 (95% CI: 0.77–0.91), specificity: 0.95 (95% CI: 0.89–0.98), AUC: 0.96 (95% CI: 0.94–0.97). Conclusion: miRNAs may be used as potential biomarkers for the detection of AMI. For single, stand-alone miRNAs, miRNA-499 may have better diagnostic accuracy compared to other miRNAs. We propose that a panel of multiple miRNAs with high sensitivity and specificity should be tested. Frontiers Media S.A. 2020-08-14 /pmc/articles/PMC7456928/ /pubmed/32922300 http://dx.doi.org/10.3389/fphys.2020.00691 Text en Copyright © 2020 Zhai, Li, Hou, Chen, Alzogool, Hu, Zhang, Zhang, Wang, Zhang and Cong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhai, ChuanNan
Li, Rui
Hou, Kai
Chen, JingYi
Alzogool, Mohammad
Hu, YueCheng
Zhang, JingXia
Zhang, YingYi
Wang, Le
Zhang, Rui
Cong, HongLiang
Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title_full Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title_fullStr Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title_full_unstemmed Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title_short Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis
title_sort value of blood-based micrornas in the diagnosis of acute myocardial infarction: a systematic review and meta-analysis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456928/
https://www.ncbi.nlm.nih.gov/pubmed/32922300
http://dx.doi.org/10.3389/fphys.2020.00691
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