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Partial Degradation of Recombinant Antibody Functional Activity During Infant Gastrointestinal Digestion: Implications for Oral Antibody Supplementation
Oral administration of engineered immunoglobulins has the potential to prevent enteric pathogen-induced diarrhea in infants. To prevent infection, these antibodies need to survive functionally intact in the proteolytic environment of the gastrointestinal tract. This research examined both ex vivo an...
Autores principales: | Sah, Baidya Nath P., Lueangsakulthai, Jiraporn, Kim, Bum Jin, Hauser, Benjamin R., Woo, Yeonhee, Olyaei, Amy, Aloia, Molly, O'Connor, Ann, Scottoline, Brian, Pastey, Manoj K., Dallas, David C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456970/ https://www.ncbi.nlm.nih.gov/pubmed/32923453 http://dx.doi.org/10.3389/fnut.2020.00130 |
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