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The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease

Cardiovascular disease (CVD) is currently one of the primary causes of mortality and morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in regulating stem cell behavior because of their special features, including shape, size, aspect ratio, surface charge, and surface...

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Detalles Bibliográficos
Autores principales: Sun, Yuting, Lu, Yuexin, Yin, Li, Liu, Zhenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457042/
https://www.ncbi.nlm.nih.gov/pubmed/32923434
http://dx.doi.org/10.3389/fbioe.2020.00947
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author Sun, Yuting
Lu, Yuexin
Yin, Li
Liu, Zhenjie
author_facet Sun, Yuting
Lu, Yuexin
Yin, Li
Liu, Zhenjie
author_sort Sun, Yuting
collection PubMed
description Cardiovascular disease (CVD) is currently one of the primary causes of mortality and morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in regulating stem cell behavior because of their special features, including shape, size, aspect ratio, surface charge, and surface area. In terms of cardiac disease, NPs can facilitate gene delivery in stem cells, track the stem cells in vivo for long-term monitoring, and enhance retention after their transplantation. The advantages of applying NPs in peripheral vascular disease treatments include facilitating stem cell therapy, mimicking the extracellular matrix environment, and utilizing a safe non-viral gene delivery tool. However, the main limitation of NPs is toxicity, which is related to their size, shape, aspect ratio, and surface charge. Currently, there have been many animal models proving NPs’ potential in treating CVD, but no extensive applications of stem-cell therapy using NPs are available in clinical practice. In conclusion, NPs might have significant potential uses in clinical trials of CVD in the future, thereby meeting the changing needs of individual patients worldwide.
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spelling pubmed-74570422020-09-11 The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease Sun, Yuting Lu, Yuexin Yin, Li Liu, Zhenjie Front Bioeng Biotechnol Bioengineering and Biotechnology Cardiovascular disease (CVD) is currently one of the primary causes of mortality and morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in regulating stem cell behavior because of their special features, including shape, size, aspect ratio, surface charge, and surface area. In terms of cardiac disease, NPs can facilitate gene delivery in stem cells, track the stem cells in vivo for long-term monitoring, and enhance retention after their transplantation. The advantages of applying NPs in peripheral vascular disease treatments include facilitating stem cell therapy, mimicking the extracellular matrix environment, and utilizing a safe non-viral gene delivery tool. However, the main limitation of NPs is toxicity, which is related to their size, shape, aspect ratio, and surface charge. Currently, there have been many animal models proving NPs’ potential in treating CVD, but no extensive applications of stem-cell therapy using NPs are available in clinical practice. In conclusion, NPs might have significant potential uses in clinical trials of CVD in the future, thereby meeting the changing needs of individual patients worldwide. Frontiers Media S.A. 2020-08-14 /pmc/articles/PMC7457042/ /pubmed/32923434 http://dx.doi.org/10.3389/fbioe.2020.00947 Text en Copyright © 2020 Sun, Lu, Yin and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Sun, Yuting
Lu, Yuexin
Yin, Li
Liu, Zhenjie
The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title_full The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title_fullStr The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title_full_unstemmed The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title_short The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease
title_sort roles of nanoparticles in stem cell-based therapy for cardiovascular disease
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457042/
https://www.ncbi.nlm.nih.gov/pubmed/32923434
http://dx.doi.org/10.3389/fbioe.2020.00947
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