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CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

BACKGROUND: Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and not well-defined due to the lack of appropriate animal mode...

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Detalles Bibliográficos
Autores principales:	Maddineni, Prabhavathi, Kasetti, Ramesh B., Patel, Pinkal D., Millar, J. Cameron, Kiehlbauch, Charles, Clark, Abbot F., Zode, Gulab S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457267/ https://www.ncbi.nlm.nih.gov/pubmed/32854767 http://dx.doi.org/10.1186/s13024-020-00400-9

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