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Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis
BACKGROUND: Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate the asso...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457363/ https://www.ncbi.nlm.nih.gov/pubmed/32867744 http://dx.doi.org/10.1186/s12893-020-00848-y |
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author | Danwang, Celestin Agbor, Valirie Ndip Bigna, Jean Joel |
author_facet | Danwang, Celestin Agbor, Valirie Ndip Bigna, Jean Joel |
author_sort | Danwang, Celestin |
collection | PubMed |
description | BACKGROUND: Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate the association between obesity and outcomes of patients after laparoscopic adrenalectomy. METHODS: We searched EMBASE, PubMed, Global Index Medicus, and Web of Science, without language restriction, to identify cohort studies published between January 1, 2000 and November 6, 2019. We considered studies with data comparing outcomes of adults with and without obesity after laparoscopic adrenalectomy. Random-effects meta-analysis was used to pool study-specific estimates. This review was registered with PROSPERO, CRD42018117070. RESULTS: Five studies with data on a pooled sample of 353 patients with obesity and 828 without were included in the meta-analysis. The risk of bias was moderate to low. We found no association between obesity and the various stages of postoperative complications: Clavien-Dindo grade 1 (OR = 1.57; 95%CI = 0.55–4.48; I(2) = 44.6%), grade 2 (OR = 1.12; 95%CI = 0.54–2.32; I(2) = 0.0%), grade 3 (OR = 1.79; 95%CI = 0.58–5.47; I(2) = 0.0%;), grade 4 (OR = 0.43; 95%CI = 0.05–3.71; I(2) = 0.0%), and grade 5 (death) (OR = 0.43; 95% CI = 0.02–14.31). Furthermore, no association was found between obesity and readmission rates (OR = 0.7; 95% CI = 0.13–3.62) and conversion of laparoscopic to open surgery (OR = 0.62; 95% CI = 0.16–2.34; I(2) = 19.5%). CONCLUSIONS: This study suggests that obesity is not associated with complications following laparoscopic adrenalectomy. This meta-analysis might have been underpowered to detect a true association between obesity and patient outcome after laparoscopic adrenalectomy due to the small number of included studies. Larger studies are needed to clarify the role of obesity in patients undergoing laparoscopic adrenalectomy. |
format | Online Article Text |
id | pubmed-7457363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74573632020-08-31 Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis Danwang, Celestin Agbor, Valirie Ndip Bigna, Jean Joel BMC Surg Research Article BACKGROUND: Studies have suggested differences in postoperative outcomes between patients with obesity and those without following adrenalectomy, but these remained to be ascertained with synthesis of available evidence. The aim of this systematic review and meta-analysis was to investigate the association between obesity and outcomes of patients after laparoscopic adrenalectomy. METHODS: We searched EMBASE, PubMed, Global Index Medicus, and Web of Science, without language restriction, to identify cohort studies published between January 1, 2000 and November 6, 2019. We considered studies with data comparing outcomes of adults with and without obesity after laparoscopic adrenalectomy. Random-effects meta-analysis was used to pool study-specific estimates. This review was registered with PROSPERO, CRD42018117070. RESULTS: Five studies with data on a pooled sample of 353 patients with obesity and 828 without were included in the meta-analysis. The risk of bias was moderate to low. We found no association between obesity and the various stages of postoperative complications: Clavien-Dindo grade 1 (OR = 1.57; 95%CI = 0.55–4.48; I(2) = 44.6%), grade 2 (OR = 1.12; 95%CI = 0.54–2.32; I(2) = 0.0%), grade 3 (OR = 1.79; 95%CI = 0.58–5.47; I(2) = 0.0%;), grade 4 (OR = 0.43; 95%CI = 0.05–3.71; I(2) = 0.0%), and grade 5 (death) (OR = 0.43; 95% CI = 0.02–14.31). Furthermore, no association was found between obesity and readmission rates (OR = 0.7; 95% CI = 0.13–3.62) and conversion of laparoscopic to open surgery (OR = 0.62; 95% CI = 0.16–2.34; I(2) = 19.5%). CONCLUSIONS: This study suggests that obesity is not associated with complications following laparoscopic adrenalectomy. This meta-analysis might have been underpowered to detect a true association between obesity and patient outcome after laparoscopic adrenalectomy due to the small number of included studies. Larger studies are needed to clarify the role of obesity in patients undergoing laparoscopic adrenalectomy. BioMed Central 2020-08-31 /pmc/articles/PMC7457363/ /pubmed/32867744 http://dx.doi.org/10.1186/s12893-020-00848-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Danwang, Celestin Agbor, Valirie Ndip Bigna, Jean Joel Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title | Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_full | Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_fullStr | Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_full_unstemmed | Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_short | Obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
title_sort | obesity and postoperative outcomes of the patients with laparoscopic adrenalectomy: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457363/ https://www.ncbi.nlm.nih.gov/pubmed/32867744 http://dx.doi.org/10.1186/s12893-020-00848-y |
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