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Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study

BACKGROUND: Topical diclofenac, a nonsteroidal anti-inflammatory drug, has proven efficacy and safety in the management of osteoarthritis pain. We investigated penetration of topical diclofenac into knee synovial tissue and fluid (primary objective) and evaluated relative exposure in the knee versus...

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Detalles Bibliográficos
Autores principales:	Seefried, Lothar, Blyth, Mark, Maheshwari, Rohit, McDonnell, Stephen M., Frappin, Guillaume, Hagen, Martina, Maybaum, Nadine, Moreira, Sebastian, Pandit, Hemant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457412/ https://www.ncbi.nlm.nih.gov/pubmed/32922524 http://dx.doi.org/10.1177/1759720X20943088

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