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AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations
BACKGROUND: Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth muscle cells (SMCs) coverage. However, the underlying mechanism of interaction b...
Autores principales: | Si, Yameng, Huang, Jiadong, Li, Xiang, Fu, Yu, Xu, Rongyao, Du, Yifei, Cheng, Jie, Jiang, Hongbing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457504/ https://www.ncbi.nlm.nih.gov/pubmed/32867785 http://dx.doi.org/10.1186/s12964-020-00606-w |
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