The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in spinocerebellar ataxias (SCAs) such as Machado-Joseph disease/SCA type 3 (MJD/SCA3), a genetic disorder, triggered by polyglutamine-expanded ataxin-3. To investigat...

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Detalles Bibliográficos
Autores principales: Duarte Lobo, Diana, Nobre, Rui Jorge, Oliveira Miranda, Catarina, Pereira, Dina, Castelhano, João, Sereno, José, Koeppen, Arnulf, Castelo-Branco, Miguel, Pereira de Almeida, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457506/
https://www.ncbi.nlm.nih.gov/pubmed/32867861
http://dx.doi.org/10.1186/s40478-020-00955-0

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