Theoretical basis for stabilizing messenger RNA through secondary structure design

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RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to form double-stranded regions, which are protected f...

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Detalles Bibliográficos
Autores principales: Wayment-Steele, Hannah K., Kim, Do Soon, Choe, Christian A., Nicol, John J., Wellington-Oguri, Roger, Watkins, Andrew M., Sperberg, R. Andres Parra, Huang, Po-Ssu, Participants, Eterna, Das, Rhiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457604/
https://www.ncbi.nlm.nih.gov/pubmed/32869022
http://dx.doi.org/10.1101/2020.08.22.262931
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