Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness(1).Prior clinical studies have identified adverse events(1,2), and remdesivir has been shown to inhibit mitochondrial RNA p...

Descripción completa

Detalles Bibliográficos
Autores principales: Akinci, Ersin, Cha, Minsun, Lin, Lin, Yeo, Grace, Hamilton, Marisa C., Donahue, Callie J., Bermudez-Cabrera, Heysol C., Zanetti, Larissa C., Chen, Maggie, Barkal, Sammy A., Khowpinitchai, Benyapa, Chu, Nam, Velimirovic, Minja, Jodhani, Rikita, Fife, James D., Sovrovic, Miha, Cole, Philip A., Davey, Robert A., Cassa, Christopher A., Sherwood, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457617/
https://www.ncbi.nlm.nih.gov/pubmed/32869031
http://dx.doi.org/10.1101/2020.08.27.270819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457617/
https://www.ncbi.nlm.nih.gov/pubmed/32869031
http://dx.doi.org/10.1101/2020.08.27.270819

Ejemplares similares