Cargando…

Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study

Patients who use post-exposure prophylaxis (PEP) are at ongoing risk for HIV acquisition after completing PEP. While the Centers for Disease Control and Prevention recommends pre-exposure prophylaxis (PrEP) use immediately after PEP, some practitioners are hesitant to offer PEP-to-PrEP (PEP2PrEP). W...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Byrne, Patrick, Orser, Lauren, Vandyk, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457653/
https://www.ncbi.nlm.nih.gov/pubmed/32856549
http://dx.doi.org/10.1177/2325958220939763
_version_ 1783576038159155200
author O’Byrne, Patrick
Orser, Lauren
Vandyk, Amanda
author_facet O’Byrne, Patrick
Orser, Lauren
Vandyk, Amanda
author_sort O’Byrne, Patrick
collection PubMed
description Patients who use post-exposure prophylaxis (PEP) are at ongoing risk for HIV acquisition after completing PEP. While the Centers for Disease Control and Prevention recommends pre-exposure prophylaxis (PrEP) use immediately after PEP, some practitioners are hesitant to offer PEP-to-PrEP (PEP2PrEP). We began offering PEP2PrEP in the sexually transmitted infection clinic in Ottawa, Canada on August 5, 2018. During the first 16 months of PEP2PrEP, 61 patients requested PEP and 46 were initiated; 30 of these patients agreed to PEP2PrEP and 26 followed through. None of our PEP patients had confirmed HIV exposures; all fulfilled the initiation criterion of condomless anal sex with a male partner of unknown HIV-status. During the study, the number of PEP requests and initiations was statistical unchanged, yet the seroconversion rate among patients who used PEP decreased from 1.7% pre-PEP2PrEP to 0% post-PEP2PrEP. Regarding follow-up, most discontinuations occurred between the PrEP intake and 1-month follow-up visit.
format Online
Article
Text
id pubmed-7457653
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-74576532020-09-11 Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study O’Byrne, Patrick Orser, Lauren Vandyk, Amanda J Int Assoc Provid AIDS Care Original Manuscript Patients who use post-exposure prophylaxis (PEP) are at ongoing risk for HIV acquisition after completing PEP. While the Centers for Disease Control and Prevention recommends pre-exposure prophylaxis (PrEP) use immediately after PEP, some practitioners are hesitant to offer PEP-to-PrEP (PEP2PrEP). We began offering PEP2PrEP in the sexually transmitted infection clinic in Ottawa, Canada on August 5, 2018. During the first 16 months of PEP2PrEP, 61 patients requested PEP and 46 were initiated; 30 of these patients agreed to PEP2PrEP and 26 followed through. None of our PEP patients had confirmed HIV exposures; all fulfilled the initiation criterion of condomless anal sex with a male partner of unknown HIV-status. During the study, the number of PEP requests and initiations was statistical unchanged, yet the seroconversion rate among patients who used PEP decreased from 1.7% pre-PEP2PrEP to 0% post-PEP2PrEP. Regarding follow-up, most discontinuations occurred between the PrEP intake and 1-month follow-up visit. SAGE Publications 2020-08-28 /pmc/articles/PMC7457653/ /pubmed/32856549 http://dx.doi.org/10.1177/2325958220939763 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
O’Byrne, Patrick
Orser, Lauren
Vandyk, Amanda
Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title_full Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title_fullStr Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title_full_unstemmed Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title_short Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study
title_sort immediate prep after pep: results from an observational nurse-led pep2prep study
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457653/
https://www.ncbi.nlm.nih.gov/pubmed/32856549
http://dx.doi.org/10.1177/2325958220939763
work_keys_str_mv AT obyrnepatrick immediateprepafterpepresultsfromanobservationalnurseledpep2prepstudy
AT orserlauren immediateprepafterpepresultsfromanobservationalnurseledpep2prepstudy
AT vandykamanda immediateprepafterpepresultsfromanobservationalnurseledpep2prepstudy