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Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

BACKGROUND: Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfunction. The β-site amyloid precursor protein cleavage enzyme 1...

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Detalles Bibliográficos
Autores principales:	Dey, Madhurima, Gunn-Moore, Frank J., Platt, Bettina, Smith, Terry K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457777/ https://www.ncbi.nlm.nih.gov/pubmed/32867761 http://dx.doi.org/10.1186/s12944-020-01367-8

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