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Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC

BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse. PURPOSE: The objective of this study was to construct a nov...

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Autores principales: Kong, Liang, Zhang, Shi-meng, Chu, Jia-hao, Liu, Xin-ze, Zhang, Lu, He, Si-yu, Yang, Si-min, Ju, Rui-jun, Li, Xue-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457883/
https://www.ncbi.nlm.nih.gov/pubmed/32922011
http://dx.doi.org/10.2147/IJN.S258906
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author Kong, Liang
Zhang, Shi-meng
Chu, Jia-hao
Liu, Xin-ze
Zhang, Lu
He, Si-yu
Yang, Si-min
Ju, Rui-jun
Li, Xue-tao
author_facet Kong, Liang
Zhang, Shi-meng
Chu, Jia-hao
Liu, Xin-ze
Zhang, Lu
He, Si-yu
Yang, Si-min
Ju, Rui-jun
Li, Xue-tao
author_sort Kong, Liang
collection PubMed
description BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse. PURPOSE: The objective of this study was to construct a novel CPP ((mmp)) modified vinorelbine and dioscin liposomes by two new functional materials, DSPE-PEG(2000)-MAL and CPP-PVGLIG-PEG(5000), to destroy VM channels, angiogenesis, EMT and inhibit invasion and migration. METHODS AND RESULTS: The targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPP ((mmp)) modified vinorelbine and dioscin liposomes with the ideal physicochemical properties and exhibited enhanced cellular uptake. In vitro and in vivo results showed that CPP ((mmp)) modified vinorelbine and dioscin liposomes could inhibit migration and invasion of A549 cells, destroy VM channels formation and angiogenesis, and block the EMT process. Pharmacodynamic studies showed that the targeting liposomes had obvious accumulations in tumor sites and magnificent antitumor efficiency. CONCLUSION: CPP ((mmp)) modified vinorelbine plus dioscin liposomes could provide a new strategy for NSCLC.
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spelling pubmed-74578832020-09-11 Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC Kong, Liang Zhang, Shi-meng Chu, Jia-hao Liu, Xin-ze Zhang, Lu He, Si-yu Yang, Si-min Ju, Rui-jun Li, Xue-tao Int J Nanomedicine Original Research BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse. PURPOSE: The objective of this study was to construct a novel CPP ((mmp)) modified vinorelbine and dioscin liposomes by two new functional materials, DSPE-PEG(2000)-MAL and CPP-PVGLIG-PEG(5000), to destroy VM channels, angiogenesis, EMT and inhibit invasion and migration. METHODS AND RESULTS: The targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPP ((mmp)) modified vinorelbine and dioscin liposomes with the ideal physicochemical properties and exhibited enhanced cellular uptake. In vitro and in vivo results showed that CPP ((mmp)) modified vinorelbine and dioscin liposomes could inhibit migration and invasion of A549 cells, destroy VM channels formation and angiogenesis, and block the EMT process. Pharmacodynamic studies showed that the targeting liposomes had obvious accumulations in tumor sites and magnificent antitumor efficiency. CONCLUSION: CPP ((mmp)) modified vinorelbine plus dioscin liposomes could provide a new strategy for NSCLC. Dove 2020-08-25 /pmc/articles/PMC7457883/ /pubmed/32922011 http://dx.doi.org/10.2147/IJN.S258906 Text en © 2020 Kong et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Kong, Liang
Zhang, Shi-meng
Chu, Jia-hao
Liu, Xin-ze
Zhang, Lu
He, Si-yu
Yang, Si-min
Ju, Rui-jun
Li, Xue-tao
Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title_full Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title_fullStr Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title_full_unstemmed Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title_short Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC
title_sort tumor microenvironmental responsive liposomes simultaneously encapsulating biological and chemotherapeutic drugs for enhancing antitumor efficacy of nsclc
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457883/
https://www.ncbi.nlm.nih.gov/pubmed/32922011
http://dx.doi.org/10.2147/IJN.S258906
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