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The estimation of diagnostic accuracy of tests for COVID-19: A scoping review
OBJECTIVES: To assess the methodologies used in the estimation of diagnostic accuracy of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other nucleic acid amplification tests (NAATs) and to evaluate the quality and reliability of the studies employing those method...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Infection Association. Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457918/ https://www.ncbi.nlm.nih.gov/pubmed/32882315 http://dx.doi.org/10.1016/j.jinf.2020.08.043 |
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author | Axell-House, Dierdre B. Lavingia, Richa Rafferty, Megan Clark, Eva Amirian, E. Susan Chiao, Elizabeth Y. |
author_facet | Axell-House, Dierdre B. Lavingia, Richa Rafferty, Megan Clark, Eva Amirian, E. Susan Chiao, Elizabeth Y. |
author_sort | Axell-House, Dierdre B. |
collection | PubMed |
description | OBJECTIVES: To assess the methodologies used in the estimation of diagnostic accuracy of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other nucleic acid amplification tests (NAATs) and to evaluate the quality and reliability of the studies employing those methods. METHODS: We conducted a systematic search of English-language articles published December 31, 2019-June 19, 2020. Studies of any design that performed tests on ≥10 patients and reported or inferred correlative statistics were included. Studies were evaluated using elements of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) guidelines. RESULTS: We conducted a narrative and tabular synthesis of studies organized by their reference standard strategy or comparative agreement method, resulting in six categorizations. Critical study details were frequently unreported, including the mechanism for patient/sample selection and researcher blinding to results, which lead to concern for bias. CONCLUSIONS: Current studies estimating test performance characteristics have imperfect study design and statistical methods for the estimation of test performance characteristics of SARS-CoV-2 tests. The included studies employ heterogeneous methods and overall have an increased risk of bias. Employing standardized guidelines for study designs and statistical methods will improve the process for developing and validating rRT-PCR and NAAT for the diagnosis of COVID-19. |
format | Online Article Text |
id | pubmed-7457918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The British Infection Association. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74579182020-09-01 The estimation of diagnostic accuracy of tests for COVID-19: A scoping review Axell-House, Dierdre B. Lavingia, Richa Rafferty, Megan Clark, Eva Amirian, E. Susan Chiao, Elizabeth Y. J Infect Article OBJECTIVES: To assess the methodologies used in the estimation of diagnostic accuracy of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other nucleic acid amplification tests (NAATs) and to evaluate the quality and reliability of the studies employing those methods. METHODS: We conducted a systematic search of English-language articles published December 31, 2019-June 19, 2020. Studies of any design that performed tests on ≥10 patients and reported or inferred correlative statistics were included. Studies were evaluated using elements of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) guidelines. RESULTS: We conducted a narrative and tabular synthesis of studies organized by their reference standard strategy or comparative agreement method, resulting in six categorizations. Critical study details were frequently unreported, including the mechanism for patient/sample selection and researcher blinding to results, which lead to concern for bias. CONCLUSIONS: Current studies estimating test performance characteristics have imperfect study design and statistical methods for the estimation of test performance characteristics of SARS-CoV-2 tests. The included studies employ heterogeneous methods and overall have an increased risk of bias. Employing standardized guidelines for study designs and statistical methods will improve the process for developing and validating rRT-PCR and NAAT for the diagnosis of COVID-19. The British Infection Association. Published by Elsevier Ltd. 2020-11 2020-08-31 /pmc/articles/PMC7457918/ /pubmed/32882315 http://dx.doi.org/10.1016/j.jinf.2020.08.043 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Axell-House, Dierdre B. Lavingia, Richa Rafferty, Megan Clark, Eva Amirian, E. Susan Chiao, Elizabeth Y. The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title | The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title_full | The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title_fullStr | The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title_full_unstemmed | The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title_short | The estimation of diagnostic accuracy of tests for COVID-19: A scoping review |
title_sort | estimation of diagnostic accuracy of tests for covid-19: a scoping review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457918/ https://www.ncbi.nlm.nih.gov/pubmed/32882315 http://dx.doi.org/10.1016/j.jinf.2020.08.043 |
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