The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study

A prospective analysis of the effect of autologous adipose derived mesenchymal stem cell (AD-MSCs) therapy in the treatment of a juvenile osteochondritis dissecans (JOCD) of the patella. After failed conventional management of JOCD, a 13-year-old patient undergoes intra-articular MSC therapy. Repeat...

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Detalles Bibliográficos
Autores principales: Russo, Alessandro, Coco, Vito, Zaffagnini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458149/
https://www.ncbi.nlm.nih.gov/pubmed/32904720
http://dx.doi.org/10.1093/jscr/rjaa274
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author Russo, Alessandro
Coco, Vito
Zaffagnini, Stefano
author_facet Russo, Alessandro
Coco, Vito
Zaffagnini, Stefano
author_sort Russo, Alessandro
collection PubMed
description A prospective analysis of the effect of autologous adipose derived mesenchymal stem cell (AD-MSCs) therapy in the treatment of a juvenile osteochondritis dissecans (JOCD) of the patella. After failed conventional management of JOCD, a 13-year-old patient undergoes intra-articular MSC therapy. Repeated magnetic resonance imaging analyses showed regeneration of cartilage. In this report, the use of AD-MSCs, after unsuccessful conventional JOCD management, resulted in structural, functional and pain improvement. These results highlight the possibility to avoid surgery treatment in JOCD patella treatment.
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spelling pubmed-74581492020-09-03 The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study Russo, Alessandro Coco, Vito Zaffagnini, Stefano J Surg Case Rep Case Report A prospective analysis of the effect of autologous adipose derived mesenchymal stem cell (AD-MSCs) therapy in the treatment of a juvenile osteochondritis dissecans (JOCD) of the patella. After failed conventional management of JOCD, a 13-year-old patient undergoes intra-articular MSC therapy. Repeated magnetic resonance imaging analyses showed regeneration of cartilage. In this report, the use of AD-MSCs, after unsuccessful conventional JOCD management, resulted in structural, functional and pain improvement. These results highlight the possibility to avoid surgery treatment in JOCD patella treatment. Oxford University Press 2020-08-31 /pmc/articles/PMC7458149/ /pubmed/32904720 http://dx.doi.org/10.1093/jscr/rjaa274 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2020. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Russo, Alessandro
Coco, Vito
Zaffagnini, Stefano
The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title_full The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title_fullStr The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title_full_unstemmed The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title_short The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
title_sort effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458149/
https://www.ncbi.nlm.nih.gov/pubmed/32904720
http://dx.doi.org/10.1093/jscr/rjaa274
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