A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development

Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. One of the most critical signaling pathways in HNSCC is the Epidermal Growth Factor Receptor/ Phosphatidylinositol 3-Kinase (EGFR/PI3K) pathway. IQ motif-containing GTPase- activating protein 1 (IQGAP1), a pro...

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Detalles Bibliográficos
Autores principales: Wei, Tao, Lambert, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458336/
https://www.ncbi.nlm.nih.gov/pubmed/32923516
http://dx.doi.org/10.18632/oncoscience.511
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author Wei, Tao
Lambert, Paul F.
author_facet Wei, Tao
Lambert, Paul F.
author_sort Wei, Tao
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. One of the most critical signaling pathways in HNSCC is the Epidermal Growth Factor Receptor/ Phosphatidylinositol 3-Kinase (EGFR/PI3K) pathway. IQ motif-containing GTPase- activating protein 1 (IQGAP1), a protein upregulated in multiple types of cancer, acts as a scaffold for this pathway and others implicated in cancer. IQGAP1 is overexpressed in HNSCCs, and its overexpression correlates with poorer prognosis in HNSCC patients, indicating that IQGAP1 might be important in HNSCC development. Here, we summarized our recent demonstrating a role of IQGAP1 in promoting HNSCC, at least in part, by scaffolding the EGFR/PI3K signaling pathway.
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spelling pubmed-74583362020-09-11 A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development Wei, Tao Lambert, Paul F. Oncoscience Research Perspective Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. One of the most critical signaling pathways in HNSCC is the Epidermal Growth Factor Receptor/ Phosphatidylinositol 3-Kinase (EGFR/PI3K) pathway. IQ motif-containing GTPase- activating protein 1 (IQGAP1), a protein upregulated in multiple types of cancer, acts as a scaffold for this pathway and others implicated in cancer. IQGAP1 is overexpressed in HNSCCs, and its overexpression correlates with poorer prognosis in HNSCC patients, indicating that IQGAP1 might be important in HNSCC development. Here, we summarized our recent demonstrating a role of IQGAP1 in promoting HNSCC, at least in part, by scaffolding the EGFR/PI3K signaling pathway. Impact Journals LLC 2020-06-07 /pmc/articles/PMC7458336/ /pubmed/32923516 http://dx.doi.org/10.18632/oncoscience.511 Text en Copyright: © 2020 Wei and Lambert. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Wei, Tao
Lambert, Paul F.
A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title_full A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title_fullStr A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title_full_unstemmed A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title_short A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
title_sort highway to carcinogenesis: the role of iqgap1, a signaling scaffolding protein, in head and neck cancer development
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458336/
https://www.ncbi.nlm.nih.gov/pubmed/32923516
http://dx.doi.org/10.18632/oncoscience.511
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