Cargando…

Targeting MmpL3 for anti-tuberculosis drug development

The unique architecture of the mycobacterial cell envelope plays an important role in Mycobacterium tuberculosis (Mtb) pathogenesis. A critical protein in cell envelope biogenesis in mycobacteria, required for transport of precursors, trehalose monomycolates (TMMs), is the Mycobacterial membrane pro...

Descripción completa

Detalles Bibliográficos
Autor principal:	Bolla, Jani R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458404/ https://www.ncbi.nlm.nih.gov/pubmed/32662825 http://dx.doi.org/10.1042/BST20190950

Ejemplares similares

Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors
por: McNeil, Matthew B., et al.
Publicado: (2020)

MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
por: Melly, Geoff, et al.
Publicado: (2019)

Coexpression of MmpS5 and MmpL5 Contributes to Both Efflux Transporter MmpL5 Trimerization and Drug Resistance in Mycobacterium tuberculosis
por: Yamamoto, Kentaro, et al.
Publicado: (2021)

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis
por: Li, Ming, et al.
Publicado: (2020)

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis
por: Grover, Shipra, et al.
Publicado: (2020)

Nano-Based Drug Delivery Systems of Potent MmpL3 Inhibitors for Tuberculosis Treatment
por: Hanieh, Patrizia Nadia, et al.
Publicado: (2022)

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections
por: Li, Wei, et al.
Publicado: (2018)

Molecular Mechanisms of MmpL3 Function and Inhibition
por: Williams, John T., et al.
Publicado: (2023)

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression
por: Degiacomi, Giulia, et al.
Publicado: (2017)

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor
por: Berube, Bryan, et al.
Publicado: (2023)

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target
por: Adams, Oliver, et al.
Publicado: (2021)

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor
por: Berube, Bryan, et al.
Publicado: (2023)

Use of Soluble Extracellular Regions of MmpL (SERoM) as Vaccines for Tuberculosis
por: Strong, Emily J., et al.
Publicado: (2018)

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
por: Li, Wei, et al.
Publicado: (2019)

Inhibition Mechanism of Anti-TB Drug SQ109: Allosteric Inhibition of TMM Translocation of Mycobacterium Tuberculosis MmpL3 Transporter
por: Carbone, Justin, et al.
Publicado: (2023)

MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections
por: Sethiya, Jigar P., et al.
Publicado: (2020)

Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
por: Li, Wei, et al.
Publicado: (2017)

Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors
por: Stevens, Casey M., et al.
Publicado: (2022)

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
por: Ahmed, Mohamed, et al.
Publicado: (2022)

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
por: Ray, Peter C., et al.
Publicado: (2021)

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
por: Varela, Cristian, et al.
Publicado: (2012)

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria
por: Fay, Allison, et al.
Publicado: (2019)

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
por: Shetty, Annanya, et al.
Publicado: (2018)

Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs
por: Couston, Julie, et al.
Publicado: (2023)

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection
por: Poce, Giovanna, et al.
Publicado: (2013)

The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation
por: Parish, Tanya
Publicado: (2022)

MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature
por: Imran, Mohd., et al.
Publicado: (2022)

Structure-function analysis of MmpL7-mediated lipid transport in mycobacteria
por: Moolla, Nabiela, et al.
Publicado: (2021)

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport
por: Su, Chih-Chia, et al.
Publicado: (2021)

A Hydrazine–Hydrazone Adamantine Compound Shows Antimycobacterial Activity and Is a Probable Inhibitor of MmpL3
por: Briffotaux, Julien, et al.
Publicado: (2022)

Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function
por: Bothra, Ankur, et al.
Publicado: (2018)

The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria
por: Belardinelli, Juan Manuel, et al.
Publicado: (2019)

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
por: Moorey, Alice R., et al.
Publicado: (2021)

MmpS5-MmpL5 Transporters Provide Mycobacterium smegmatis Resistance to imidazo[1,2-b][1,2,4,5]tetrazines
por: Maslov, Dmitry A., et al.
Publicado: (2020)

Multi-epitope vaccine candidates based on mycobacterial membrane protein large (MmpL) proteins against Mycobacterium ulcerans
por: Ishwarlall, Tamara Z., et al.
Publicado: (2023)

Repurposing Based Identification of Novel Inhibitors against MmpS5-MmpL5 Efflux Pump of Mycobacterium smegmatis: A Combined In Silico and In Vitro Study
por: Shahbaaz, Mohd, et al.
Publicado: (2022)

Two putative MmpL homologs contribute to antimicrobial resistance and nephropathy of enterohemorrhagic E. coli O157:H7
por: Hussein, Salma H., et al.
Publicado: (2019)

Study of SQ109 analogs binding to mycobacterium MmpL3 transporter using MD simulations and alchemical relative binding free energy calculations
por: Stampolaki, Marianna, et al.
Publicado: (2023)

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
por: Remuiñán, Modesto J., et al.
Publicado: (2013)

In vivo imaging of MmpL transporters reveals distinct subcellular locations for export of mycolic acids and non-essential trehalose polyphleates in the mycobacterial outer membrane
por: Thouvenel, Laurie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o94e2s15ajo5fd7oldakubf39t