Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

The NMDA receptor (NMDAR) is inhibited by synaptically released zinc. This inhibition is thought to be the result of zinc diffusion across the synaptic cleft and subsequent binding to the extracellular domain of the NMDAR. However, this model fails to incorporate the observed association of the high...

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Detalles Bibliográficos
Autores principales: Krall, Rebecca F., Moutal, Aubin, Phillips, Matthew B., Asraf, Hila, Johnson, Jon W., Khanna, Rajesh, Hershfinkel, Michal, Aizenman, Elias, Tzounopoulos, Thanos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458442/
https://www.ncbi.nlm.nih.gov/pubmed/32937457
http://dx.doi.org/10.1126/sciadv.abb1515

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