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Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
The stringent expression of the hypoxia inducible factor-1α (HIF-1α) is critical to a variety of pathophysiological conditions. We reveal that, in normoxia, enzymatic action of cystathionine β-synthase (CBS) produces H(2)S, which persulfidates prolyl hydroxylase 2 (PHD2) at residues Cys(21) and Cys(...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458453/ https://www.ncbi.nlm.nih.gov/pubmed/32937467 http://dx.doi.org/10.1126/sciadv.aaz8534 |