Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer’s Disease Mice, Independent of Amyloid-β Pathology

BACKGROUND: Soluble oligomeric amyloid-β (Aβ), rather than Aβ plaques, seems to be the culprit in Alzheimer’s disease (AD). Accordingly, a new concept vaccine of small cyclic peptide conjugates, selectively targeting oligomeric Aβ, has been developed. OBJECTIVE: Study the therapeutic potential of th...

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Detalles Bibliográficos
Autores principales: Oberman, Klaske, Gouweleeuw, Leonie, Hoogerhout, Peter, Eisel, Ulrich L.M., van Riet, Elly, Schoemaker, Regien G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458552/
https://www.ncbi.nlm.nih.gov/pubmed/32904788
http://dx.doi.org/10.3233/ADR-200213

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