IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8(+) T-cell responses

Antitumor immunity is mediated by Th1 CD4(+) and CD8(+) T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4(+) T cells have been described to promote tumor growth. Here, we explored the influence of IL-17 on the ability of therapeutic vaccines to induce the rejection of tumors in...

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Detalles Bibliográficos
Autores principales: Dadaglio, Gilles, Fayolle, Catherine, Oberkampf, Marine, Tang, Alexandre, Rudilla, Francesc, Couillin, Isabelle, Torheim, Eirik A., Rosenbaum, Pierre, Leclerc, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458594/
https://www.ncbi.nlm.nih.gov/pubmed/32923117
http://dx.doi.org/10.1080/2162402X.2020.1758606

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