Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

The tumoricidal efficiency of human CAR-T cells is generally evaluated using immune-deficient mouse models; however, due to their immune-incompetency and the species-specific reactivity of a target antigen, these models are problematic to imitate CAR-T-induced adverse effects in the clinic. Epitheli...

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Detalles Bibliográficos
Autores principales: Qin, Diyuan, Li, Dan, Zhang, Benxia, Chen, Yue, Liao, Xuelian, Li, Xiaoyu, Alexander, Peter B., Wang, Yongsheng, Li, Qi-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458607/
https://www.ncbi.nlm.nih.gov/pubmed/32923168
http://dx.doi.org/10.1080/2162402X.2020.1806009

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