NK cells beat T cells at early breast cancer control

Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8(+) T cells. Our findings demonstrate that CD8(+) T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role...

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Detalles Bibliográficos
Autores principales: Buque, Aitziber, Bloy, Norma, Petroni, Giulia, Kroemer, Guido, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458610/
https://www.ncbi.nlm.nih.gov/pubmed/32923169
http://dx.doi.org/10.1080/2162402X.2020.1806010
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author Buque, Aitziber
Bloy, Norma
Petroni, Giulia
Kroemer, Guido
Galluzzi, Lorenzo
author_facet Buque, Aitziber
Bloy, Norma
Petroni, Giulia
Kroemer, Guido
Galluzzi, Lorenzo
author_sort Buque, Aitziber
collection PubMed
description Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8(+) T cells. Our findings demonstrate that CD8(+) T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.
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spelling pubmed-74586102020-09-11 NK cells beat T cells at early breast cancer control Buque, Aitziber Bloy, Norma Petroni, Giulia Kroemer, Guido Galluzzi, Lorenzo Oncoimmunology Editorial Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8(+) T cells. Our findings demonstrate that CD8(+) T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting. Taylor & Francis 2020-08-23 /pmc/articles/PMC7458610/ /pubmed/32923169 http://dx.doi.org/10.1080/2162402X.2020.1806010 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Buque, Aitziber
Bloy, Norma
Petroni, Giulia
Kroemer, Guido
Galluzzi, Lorenzo
NK cells beat T cells at early breast cancer control
title NK cells beat T cells at early breast cancer control
title_full NK cells beat T cells at early breast cancer control
title_fullStr NK cells beat T cells at early breast cancer control
title_full_unstemmed NK cells beat T cells at early breast cancer control
title_short NK cells beat T cells at early breast cancer control
title_sort nk cells beat t cells at early breast cancer control
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458610/
https://www.ncbi.nlm.nih.gov/pubmed/32923169
http://dx.doi.org/10.1080/2162402X.2020.1806010
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AT kroemerguido nkcellsbeattcellsatearlybreastcancercontrol
AT galluzzilorenzo nkcellsbeattcellsatearlybreastcancercontrol

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