Mitochondrial control of innate immune signaling by irradiated cancer cells

Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS...

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Detalles Bibliográficos
Autores principales: Yamazaki, Takahiro, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458622/
https://www.ncbi.nlm.nih.gov/pubmed/32923160
http://dx.doi.org/10.1080/2162402X.2020.1797292
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author Yamazaki, Takahiro
Galluzzi, Lorenzo
author_facet Yamazaki, Takahiro
Galluzzi, Lorenzo
author_sort Yamazaki, Takahiro
collection PubMed
description Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.
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spelling pubmed-74586222020-09-11 Mitochondrial control of innate immune signaling by irradiated cancer cells Yamazaki, Takahiro Galluzzi, Lorenzo Oncoimmunology Editorial Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells. Taylor & Francis 2020-07-22 /pmc/articles/PMC7458622/ /pubmed/32923160 http://dx.doi.org/10.1080/2162402X.2020.1797292 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Yamazaki, Takahiro
Galluzzi, Lorenzo
Mitochondrial control of innate immune signaling by irradiated cancer cells
title Mitochondrial control of innate immune signaling by irradiated cancer cells
title_full Mitochondrial control of innate immune signaling by irradiated cancer cells
title_fullStr Mitochondrial control of innate immune signaling by irradiated cancer cells
title_full_unstemmed Mitochondrial control of innate immune signaling by irradiated cancer cells
title_short Mitochondrial control of innate immune signaling by irradiated cancer cells
title_sort mitochondrial control of innate immune signaling by irradiated cancer cells
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458622/
https://www.ncbi.nlm.nih.gov/pubmed/32923160
http://dx.doi.org/10.1080/2162402X.2020.1797292
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AT galluzzilorenzo mitochondrialcontrolofinnateimmunesignalingbyirradiatedcancercells

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