IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice

The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells (Tregs) play a significant role in the suppression of antitumor immunity in human glioma. Given the importance of Tregs in the overall framework o...

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Detalles Bibliográficos
Autores principales: Richardson, Leland G., Nieman, Linda T., Stemmer-Rachamimov, Anat O., Zheng, Xijin S., Stafford, Khalifa, Nagashima, Hiroaki, Miller, Julie J., Kiyokawa, Juri, Ting, David T., Wakimoto, Hiroaki, Cahill, Daniel P., Choi, Bryan D., Curry, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458656/
https://www.ncbi.nlm.nih.gov/pubmed/32923170
http://dx.doi.org/10.1080/2162402X.2020.1806662

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