Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients. Several lines of evidence suggest that the low response rate might...

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Detalles Bibliográficos
Autores principales: Brunekreeft, Kim L., Paijens, Sterre T., Wouters, Maartje C.A., Komdeur, Fenne L., Eggink, Florine A., Lubbers, Joyce M., Workel, Hagma H., Van Der Slikke, Elisabeth C., Pröpper, Noor E.J., Leffers, Ninke, Adam, Julien, Pijper, Harry, Plat, Annechien, Kol, Arjan, Nijman, Hans W., De Bruyn, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458665/
https://www.ncbi.nlm.nih.gov/pubmed/32923120
http://dx.doi.org/10.1080/2162402X.2020.1760705

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