The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence

Systemic infections due to Fusobacterium may originate in the tonsillar/internal jugular veins or from the abdomen. We encountered a patient who presented with bacteremia, fulminant septic shock, and extensive soft tissue pyogenic infection due to Fusobacterium necrophorum. In addition, there was wi...

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Autores principales: King, Martina, Hurley, Hermione, Davidson, Kevin R., Dempsey, Edward C., Barron, Michelle A., Chan, Edward D., Frey, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458797/
https://www.ncbi.nlm.nih.gov/pubmed/32895617
http://dx.doi.org/10.4110/in.2020.20.e30
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author King, Martina
Hurley, Hermione
Davidson, Kevin R.
Dempsey, Edward C.
Barron, Michelle A.
Chan, Edward D.
Frey, Amy
author_facet King, Martina
Hurley, Hermione
Davidson, Kevin R.
Dempsey, Edward C.
Barron, Michelle A.
Chan, Edward D.
Frey, Amy
author_sort King, Martina
collection PubMed
description Systemic infections due to Fusobacterium may originate in the tonsillar/internal jugular veins or from the abdomen. We encountered a patient who presented with bacteremia, fulminant septic shock, and extensive soft tissue pyogenic infection due to Fusobacterium necrophorum. In addition, there was widespread metastatic colon cancer with the unique finding of pre-mortem co-localization of F. necrophorum and cancer cells at a site distant from the colon. We reviewed the literature of the association of F. necrophorum and colon cancer, and discuss the evidence of how each of these 2 distinct entities may mutually augment the development or progression of the other.
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spelling pubmed-74587972020-09-06 The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence King, Martina Hurley, Hermione Davidson, Kevin R. Dempsey, Edward C. Barron, Michelle A. Chan, Edward D. Frey, Amy Immune Netw Review Article Systemic infections due to Fusobacterium may originate in the tonsillar/internal jugular veins or from the abdomen. We encountered a patient who presented with bacteremia, fulminant septic shock, and extensive soft tissue pyogenic infection due to Fusobacterium necrophorum. In addition, there was widespread metastatic colon cancer with the unique finding of pre-mortem co-localization of F. necrophorum and cancer cells at a site distant from the colon. We reviewed the literature of the association of F. necrophorum and colon cancer, and discuss the evidence of how each of these 2 distinct entities may mutually augment the development or progression of the other. The Korean Association of Immunologists 2020-08-04 /pmc/articles/PMC7458797/ /pubmed/32895617 http://dx.doi.org/10.4110/in.2020.20.e30 Text en Copyright © 2020. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
King, Martina
Hurley, Hermione
Davidson, Kevin R.
Dempsey, Edward C.
Barron, Michelle A.
Chan, Edward D.
Frey, Amy
The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title_full The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title_fullStr The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title_full_unstemmed The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title_short The Link between Fusobacteria and Colon Cancer: a Fulminant Example and Review of the Evidence
title_sort link between fusobacteria and colon cancer: a fulminant example and review of the evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458797/
https://www.ncbi.nlm.nih.gov/pubmed/32895617
http://dx.doi.org/10.4110/in.2020.20.e30
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