Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms

Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberra...

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Detalles Bibliográficos
Autores principales: Mohammadi, Soheil, Moosaie, Fatemeh, Aarabi, Mohammad Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458880/
https://www.ncbi.nlm.nih.gov/pubmed/32869183
http://dx.doi.org/10.1007/s12035-020-02094-y
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author Mohammadi, Soheil
Moosaie, Fatemeh
Aarabi, Mohammad Hadi
author_facet Mohammadi, Soheil
Moosaie, Fatemeh
Aarabi, Mohammad Hadi
author_sort Mohammadi, Soheil
collection PubMed
description Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement.
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spelling pubmed-74588802020-09-01 Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms Mohammadi, Soheil Moosaie, Fatemeh Aarabi, Mohammad Hadi Mol Neurobiol Article Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement. Springer US 2020-09-01 2020 /pmc/articles/PMC7458880/ /pubmed/32869183 http://dx.doi.org/10.1007/s12035-020-02094-y Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Mohammadi, Soheil
Moosaie, Fatemeh
Aarabi, Mohammad Hadi
Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title_full Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title_fullStr Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title_full_unstemmed Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title_short Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms
title_sort understanding the immunologic characteristics of neurologic manifestations of sars-cov-2 and potential immunological mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458880/
https://www.ncbi.nlm.nih.gov/pubmed/32869183
http://dx.doi.org/10.1007/s12035-020-02094-y
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