The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8

Monoclonal antibody (mAb) 10E8 recognizes a highly conserved epitope on HIV and is capable of neutralizing > 95% of circulating viral isolates making it one of the most promising Abs against HIV. Solution instability and biochemical heterogeneity of 10E8 has hampered its development for clinical...

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Detalles Bibliográficos
Autores principales: Guttman, Miklos, Padte, Neal N., Huang, Yaoxing, Yu, Jian, Rocklin, Gabriel J., Weitzner, Brian D., Scian, Michele, Ho, David D., Lee, Kelly K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458915/
https://www.ncbi.nlm.nih.gov/pubmed/32868832
http://dx.doi.org/10.1038/s41598-020-71184-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458915/
https://www.ncbi.nlm.nih.gov/pubmed/32868832
http://dx.doi.org/10.1038/s41598-020-71184-7

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