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Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging
Intraoperative visualization of lymphatic flow could guide surgeons performing laparoscopic colon cancer surgery on the extent of intestinal resection required. The purpose of this study was to investigate indocyanine green fluorescence imaging for intraoperative detection of lymphatic flow and node...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459107/ https://www.ncbi.nlm.nih.gov/pubmed/32868829 http://dx.doi.org/10.1038/s41598-020-71215-3 |
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author | Ushijima, Hokuto Kawamura, Junichiro Ueda, Kazuki Yane, Yoshinori Yoshioka, Yasumasa Daito, Koji Tokoro, Tadao Hida, Jin-ichi Okuno, Kiyotaka |
author_facet | Ushijima, Hokuto Kawamura, Junichiro Ueda, Kazuki Yane, Yoshinori Yoshioka, Yasumasa Daito, Koji Tokoro, Tadao Hida, Jin-ichi Okuno, Kiyotaka |
author_sort | Ushijima, Hokuto |
collection | PubMed |
description | Intraoperative visualization of lymphatic flow could guide surgeons performing laparoscopic colon cancer surgery on the extent of intestinal resection required. The purpose of this study was to investigate indocyanine green fluorescence imaging for intraoperative detection of lymphatic flow and nodes in such patients. All patients undergoing elective laparoscopic surgery for colorectal cancer from October 2016 to July 2017 were included in this study. Indocyanine green was injected submucosally around the tumors via a colonoscope and lymphatic flow assessed with a laparoscopic near-infrared camera system intraoperatively. Lymphatic flow was visualized perioperatively in 43 of 57 patients (75.4%). The rate of visualized lymphatic flow was significantly higher in patients with a lower clinical stage than in those with a higher clinical stage (p = 0.0103). Among the 14 patients in whom lymphatic flow was not visualized, 10 (71.4%) had cStage III or IV cancer. Our results indicate the potential role of intraoperative navigation in colon cancer surgery in early-stage colon cancers. This method allows the surgeon to clearly identify lymphatic flow during surgery and allows the determination and individualization of the lymph node dissection range. |
format | Online Article Text |
id | pubmed-7459107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74591072020-09-01 Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging Ushijima, Hokuto Kawamura, Junichiro Ueda, Kazuki Yane, Yoshinori Yoshioka, Yasumasa Daito, Koji Tokoro, Tadao Hida, Jin-ichi Okuno, Kiyotaka Sci Rep Article Intraoperative visualization of lymphatic flow could guide surgeons performing laparoscopic colon cancer surgery on the extent of intestinal resection required. The purpose of this study was to investigate indocyanine green fluorescence imaging for intraoperative detection of lymphatic flow and nodes in such patients. All patients undergoing elective laparoscopic surgery for colorectal cancer from October 2016 to July 2017 were included in this study. Indocyanine green was injected submucosally around the tumors via a colonoscope and lymphatic flow assessed with a laparoscopic near-infrared camera system intraoperatively. Lymphatic flow was visualized perioperatively in 43 of 57 patients (75.4%). The rate of visualized lymphatic flow was significantly higher in patients with a lower clinical stage than in those with a higher clinical stage (p = 0.0103). Among the 14 patients in whom lymphatic flow was not visualized, 10 (71.4%) had cStage III or IV cancer. Our results indicate the potential role of intraoperative navigation in colon cancer surgery in early-stage colon cancers. This method allows the surgeon to clearly identify lymphatic flow during surgery and allows the determination and individualization of the lymph node dissection range. Nature Publishing Group UK 2020-08-31 /pmc/articles/PMC7459107/ /pubmed/32868829 http://dx.doi.org/10.1038/s41598-020-71215-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ushijima, Hokuto Kawamura, Junichiro Ueda, Kazuki Yane, Yoshinori Yoshioka, Yasumasa Daito, Koji Tokoro, Tadao Hida, Jin-ichi Okuno, Kiyotaka Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title | Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title_full | Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title_fullStr | Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title_full_unstemmed | Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title_short | Visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
title_sort | visualization of lymphatic flow in laparoscopic colon cancer surgery using indocyanine green fluorescence imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459107/ https://www.ncbi.nlm.nih.gov/pubmed/32868829 http://dx.doi.org/10.1038/s41598-020-71215-3 |
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