[18-C-6H(3)O(+)]: an in-situ generated macrocyclic complex and an efficient, novel catalyst for synthesis of pyrano[2,3-c]pyrazole derivatives

Synthesis of small aromatic heterocycles is of greater importance in the organic chemistry due to their vibrant applications in pharmaceuticals, agrochemicals and veterinary products. Pyranopyrazoles are one such class of heterocycles associated with numerous applications. Hence herein we report a multicomponent crown ether catalyzed, ultrasound irradiated methodology to make different functionalized pyranopyrazoles in a single step. This technique involves the in-situ generation of [18-C-6H(3)O(+)][OH(−)] complex, which in turn activates the aromatic aldehyde and aids in the facile nucleophilic addition.