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Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage
Cell production and differentiation for the acquisition of specific functions are key features of living systems. The dynamic network of cellular microtubules provides the necessary platform to accommodate processes associated with the transition of cells through the individual phases of cytogenesis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459425/ https://www.ncbi.nlm.nih.gov/pubmed/32667089 http://dx.doi.org/10.15252/embj.2019104238 |
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author | Montesinos, Juan Carlos Abuzeineh, Anas Kopf, Aglaja Juanes‐Garcia, Alba Ötvös, Krisztina Petrášek, Jan Sixt, Michael Benková, Eva |
author_facet | Montesinos, Juan Carlos Abuzeineh, Anas Kopf, Aglaja Juanes‐Garcia, Alba Ötvös, Krisztina Petrášek, Jan Sixt, Michael Benková, Eva |
author_sort | Montesinos, Juan Carlos |
collection | PubMed |
description | Cell production and differentiation for the acquisition of specific functions are key features of living systems. The dynamic network of cellular microtubules provides the necessary platform to accommodate processes associated with the transition of cells through the individual phases of cytogenesis. Here, we show that the plant hormone cytokinin fine‐tunes the activity of the microtubular cytoskeleton during cell differentiation and counteracts microtubular rearrangements driven by the hormone auxin. The endogenous upward gradient of cytokinin activity along the longitudinal growth axis in Arabidopsis thaliana roots correlates with robust rearrangements of the microtubule cytoskeleton in epidermal cells progressing from the proliferative to the differentiation stage. Controlled increases in cytokinin activity result in premature re‐organization of the microtubule network from transversal to an oblique disposition in cells prior to their differentiation, whereas attenuated hormone perception delays cytoskeleton conversion into a configuration typical for differentiated cells. Intriguingly, cytokinin can interfere with microtubules also in animal cells, such as leukocytes, suggesting that a cytokinin‐sensitive control pathway for the microtubular cytoskeleton may be at least partially conserved between plant and animal cells. |
format | Online Article Text |
id | pubmed-7459425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74594252020-09-03 Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage Montesinos, Juan Carlos Abuzeineh, Anas Kopf, Aglaja Juanes‐Garcia, Alba Ötvös, Krisztina Petrášek, Jan Sixt, Michael Benková, Eva EMBO J Articles Cell production and differentiation for the acquisition of specific functions are key features of living systems. The dynamic network of cellular microtubules provides the necessary platform to accommodate processes associated with the transition of cells through the individual phases of cytogenesis. Here, we show that the plant hormone cytokinin fine‐tunes the activity of the microtubular cytoskeleton during cell differentiation and counteracts microtubular rearrangements driven by the hormone auxin. The endogenous upward gradient of cytokinin activity along the longitudinal growth axis in Arabidopsis thaliana roots correlates with robust rearrangements of the microtubule cytoskeleton in epidermal cells progressing from the proliferative to the differentiation stage. Controlled increases in cytokinin activity result in premature re‐organization of the microtubule network from transversal to an oblique disposition in cells prior to their differentiation, whereas attenuated hormone perception delays cytoskeleton conversion into a configuration typical for differentiated cells. Intriguingly, cytokinin can interfere with microtubules also in animal cells, such as leukocytes, suggesting that a cytokinin‐sensitive control pathway for the microtubular cytoskeleton may be at least partially conserved between plant and animal cells. John Wiley and Sons Inc. 2020-07-15 2020-09-01 /pmc/articles/PMC7459425/ /pubmed/32667089 http://dx.doi.org/10.15252/embj.2019104238 Text en © 2020 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Montesinos, Juan Carlos Abuzeineh, Anas Kopf, Aglaja Juanes‐Garcia, Alba Ötvös, Krisztina Petrášek, Jan Sixt, Michael Benková, Eva Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title | Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title_full | Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title_fullStr | Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title_full_unstemmed | Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title_short | Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
title_sort | phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459425/ https://www.ncbi.nlm.nih.gov/pubmed/32667089 http://dx.doi.org/10.15252/embj.2019104238 |
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