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New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action

The worldwide emergence of microbial resistance to available antibiotics presents a global threat to public health and health systems. This special issue aimed to gather papers describing novel antibiotics, originating form chemical synthesis, repurposing of existent drugs, or from natural sources l...

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Autor principal: Leitão, Jorge H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459480/
https://www.ncbi.nlm.nih.gov/pubmed/32752219
http://dx.doi.org/10.3390/antibiotics9080471
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author Leitão, Jorge H.
author_facet Leitão, Jorge H.
author_sort Leitão, Jorge H.
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description The worldwide emergence of microbial resistance to available antibiotics presents a global threat to public health and health systems. This special issue aimed to gather papers describing novel antibiotics, originating form chemical synthesis, repurposing of existent drugs, or from natural sources like plant extracts, herbs and spices. A total of 13 papers were published, covering a wide range of topic, including antimicrobial resistance surveillance studies; synthesis of novel molecules with antimicrobial activities; modification or repurposing of already existing molecules, plant-derived active extracts, and molecules; the effects of antimicrobial therapy on microbiota; and the investigation of novel formulations for human and veterinary uses. After decades of antibiotics discovery decline, antibiotics discovery is boosting. Recent developments of post genomics approaches and bioinformatics tools will most certainly turn the tide in the discovery and development of antimicrobials in this exciting field.
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spelling pubmed-74594802020-09-02 New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action Leitão, Jorge H. Antibiotics (Basel) Editorial The worldwide emergence of microbial resistance to available antibiotics presents a global threat to public health and health systems. This special issue aimed to gather papers describing novel antibiotics, originating form chemical synthesis, repurposing of existent drugs, or from natural sources like plant extracts, herbs and spices. A total of 13 papers were published, covering a wide range of topic, including antimicrobial resistance surveillance studies; synthesis of novel molecules with antimicrobial activities; modification or repurposing of already existing molecules, plant-derived active extracts, and molecules; the effects of antimicrobial therapy on microbiota; and the investigation of novel formulations for human and veterinary uses. After decades of antibiotics discovery decline, antibiotics discovery is boosting. Recent developments of post genomics approaches and bioinformatics tools will most certainly turn the tide in the discovery and development of antimicrobials in this exciting field. MDPI 2020-08-01 /pmc/articles/PMC7459480/ /pubmed/32752219 http://dx.doi.org/10.3390/antibiotics9080471 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Leitão, Jorge H.
New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title_full New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title_fullStr New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title_full_unstemmed New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title_short New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action
title_sort new insights into antibacterial compounds: from synthesis and discovery to molecular mechanisms of action
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459480/
https://www.ncbi.nlm.nih.gov/pubmed/32752219
http://dx.doi.org/10.3390/antibiotics9080471
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