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Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis

Alveolar echinococcosis (AE) is caused by the intermediate stage of Echinococcus multilocularis. We aimed to correlate computed tomography (CT) data with histology to identify distinct characteristics for different lesion types. We classified 45 samples into five types with the Echinococcus multiloc...

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Autores principales: Grimm, Johannes, Beck, Annika, Nell, Juliane, Schmidberger, Julian, Hillenbrand, Andreas, Beer, Ambros J., Dezsényi, Balázs, Shi, Rong, Beer, Meinrad, Kern, Peter, Henne-Bruns, Doris, Kratzer, Wolfgang, Moller, Peter, Barth, Thomas FE, Gruener, Beate, Graeter, Tilmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459611/
https://www.ncbi.nlm.nih.gov/pubmed/32759781
http://dx.doi.org/10.3390/pathogens9080634
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author Grimm, Johannes
Beck, Annika
Nell, Juliane
Schmidberger, Julian
Hillenbrand, Andreas
Beer, Ambros J.
Dezsényi, Balázs
Shi, Rong
Beer, Meinrad
Kern, Peter
Henne-Bruns, Doris
Kratzer, Wolfgang
Moller, Peter
Barth, Thomas FE
Gruener, Beate
Graeter, Tilmann
author_facet Grimm, Johannes
Beck, Annika
Nell, Juliane
Schmidberger, Julian
Hillenbrand, Andreas
Beer, Ambros J.
Dezsényi, Balázs
Shi, Rong
Beer, Meinrad
Kern, Peter
Henne-Bruns, Doris
Kratzer, Wolfgang
Moller, Peter
Barth, Thomas FE
Gruener, Beate
Graeter, Tilmann
author_sort Grimm, Johannes
collection PubMed
description Alveolar echinococcosis (AE) is caused by the intermediate stage of Echinococcus multilocularis. We aimed to correlate computed tomography (CT) data with histology to identify distinct characteristics for different lesion types. We classified 45 samples into five types with the Echinococcus multilocularis Ulm Classification for Computed Tomography (EMUC-CT). The various CT lesions exhibited significantly different histological parameters, which led us to propose a progression model. The initial lesion fit the CT type IV classification, which comprises a single necrotic area with the central located laminated layer, a larger distance between laminated layer and border zone, a small fibrotic peripheral zone, and few small particles of Echinococcus multilocularis (spems). Lesions could progress through CT types I, II, and III, characterized by shorter distances between laminated layer and border zone, more spems inside and surrounding the lesion, and a pronounced fibrotic rim (mostly in type III). Alternatively, lesions could converge to a highly calcified, regressive state (type V). Our results suggest that the CT types mark sequential stages of the infection, which progress over time. These distinct histological patterns advance the understanding of interactions between AE and human host; moreover, they might become prognostically and therapeutically relevant.
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spelling pubmed-74596112020-09-02 Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis Grimm, Johannes Beck, Annika Nell, Juliane Schmidberger, Julian Hillenbrand, Andreas Beer, Ambros J. Dezsényi, Balázs Shi, Rong Beer, Meinrad Kern, Peter Henne-Bruns, Doris Kratzer, Wolfgang Moller, Peter Barth, Thomas FE Gruener, Beate Graeter, Tilmann Pathogens Article Alveolar echinococcosis (AE) is caused by the intermediate stage of Echinococcus multilocularis. We aimed to correlate computed tomography (CT) data with histology to identify distinct characteristics for different lesion types. We classified 45 samples into five types with the Echinococcus multilocularis Ulm Classification for Computed Tomography (EMUC-CT). The various CT lesions exhibited significantly different histological parameters, which led us to propose a progression model. The initial lesion fit the CT type IV classification, which comprises a single necrotic area with the central located laminated layer, a larger distance between laminated layer and border zone, a small fibrotic peripheral zone, and few small particles of Echinococcus multilocularis (spems). Lesions could progress through CT types I, II, and III, characterized by shorter distances between laminated layer and border zone, more spems inside and surrounding the lesion, and a pronounced fibrotic rim (mostly in type III). Alternatively, lesions could converge to a highly calcified, regressive state (type V). Our results suggest that the CT types mark sequential stages of the infection, which progress over time. These distinct histological patterns advance the understanding of interactions between AE and human host; moreover, they might become prognostically and therapeutically relevant. MDPI 2020-08-04 /pmc/articles/PMC7459611/ /pubmed/32759781 http://dx.doi.org/10.3390/pathogens9080634 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grimm, Johannes
Beck, Annika
Nell, Juliane
Schmidberger, Julian
Hillenbrand, Andreas
Beer, Ambros J.
Dezsényi, Balázs
Shi, Rong
Beer, Meinrad
Kern, Peter
Henne-Bruns, Doris
Kratzer, Wolfgang
Moller, Peter
Barth, Thomas FE
Gruener, Beate
Graeter, Tilmann
Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title_full Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title_fullStr Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title_full_unstemmed Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title_short Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis
title_sort combining computed tomography and histology leads to an evolutionary concept of hepatic alveolar echinococcosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459611/
https://www.ncbi.nlm.nih.gov/pubmed/32759781
http://dx.doi.org/10.3390/pathogens9080634
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