Cargando…
Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics
Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patie...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459612/ https://www.ncbi.nlm.nih.gov/pubmed/32708045 http://dx.doi.org/10.3390/diagnostics10080509 |
_version_ | 1783576410297729024 |
---|---|
author | Hassan, Sammer-ul Tariq, Aamira Noreen, Zobia Donia, Ahmed Zaidi, Syed Z. J. Bokhari, Habib Zhang, Xunli |
author_facet | Hassan, Sammer-ul Tariq, Aamira Noreen, Zobia Donia, Ahmed Zaidi, Syed Z. J. Bokhari, Habib Zhang, Xunli |
author_sort | Hassan, Sammer-ul |
collection | PubMed |
description | Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community. |
format | Online Article Text |
id | pubmed-7459612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74596122020-09-02 Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics Hassan, Sammer-ul Tariq, Aamira Noreen, Zobia Donia, Ahmed Zaidi, Syed Z. J. Bokhari, Habib Zhang, Xunli Diagnostics (Basel) Review Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook of POC devices is to provide quicker analyses that can lead to well-informed clinical decisions and hence improve the health of patients at the point-of-need. Microfluidics plays an important role in the development of POC devices. However, requirements of handling expertise, pumping systems and complex fluidic controls make the technology unaffordable to the current healthcare systems in the world. In recent years, capillary-driven flow microfluidics has emerged as an attractive microfluidic-based technology to overcome these limitations by offering robust, cost-effective and simple-to-operate devices. The internal wall of the microchannels can be pre-coated with reagents, and by merely dipping the device into the patient sample, the sample can be loaded into the microchannel driven by capillary forces and can be detected via handheld or smartphone-based detectors. The capabilities of capillary-driven flow devices have not been fully exploited in developing POC diagnostics, especially for antimicrobial resistance studies in clinical settings. The purpose of this review is to open up this field of microfluidics to the ever-expanding microfluidic-based scientific community. MDPI 2020-07-22 /pmc/articles/PMC7459612/ /pubmed/32708045 http://dx.doi.org/10.3390/diagnostics10080509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hassan, Sammer-ul Tariq, Aamira Noreen, Zobia Donia, Ahmed Zaidi, Syed Z. J. Bokhari, Habib Zhang, Xunli Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title | Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title_full | Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title_fullStr | Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title_full_unstemmed | Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title_short | Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics |
title_sort | capillary-driven flow microfluidics combined with smartphone detection: an emerging tool for point-of-care diagnostics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459612/ https://www.ncbi.nlm.nih.gov/pubmed/32708045 http://dx.doi.org/10.3390/diagnostics10080509 |
work_keys_str_mv | AT hassansammerul capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT tariqaamira capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT noreenzobia capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT doniaahmed capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT zaidisyedzj capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT bokharihabib capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics AT zhangxunli capillarydrivenflowmicrofluidicscombinedwithsmartphonedetectionanemergingtoolforpointofcarediagnostics |