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Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents

The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no hist...

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Autores principales: Hattori, Hiroko, Hirata, Aya, Kubo, Sachimi, Nishida, Yoko, Nozawa, Miki, Kawamura, Kuniko, Hirata, Takumi, Kubota, Yoshimi, Sata, Mizuki, Kuwabara, Kazuyo, Higashiyama, Aya, Kadota, Aya, Sugiyama, Daisuke, Miyamatsu, Naomi, Miyamoto, Yoshihiro, Okamura, Tomonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459630/
https://www.ncbi.nlm.nih.gov/pubmed/32796692
http://dx.doi.org/10.3390/ijerph17165811
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author Hattori, Hiroko
Hirata, Aya
Kubo, Sachimi
Nishida, Yoko
Nozawa, Miki
Kawamura, Kuniko
Hirata, Takumi
Kubota, Yoshimi
Sata, Mizuki
Kuwabara, Kazuyo
Higashiyama, Aya
Kadota, Aya
Sugiyama, Daisuke
Miyamatsu, Naomi
Miyamoto, Yoshihiro
Okamura, Tomonori
author_facet Hattori, Hiroko
Hirata, Aya
Kubo, Sachimi
Nishida, Yoko
Nozawa, Miki
Kawamura, Kuniko
Hirata, Takumi
Kubota, Yoshimi
Sata, Mizuki
Kuwabara, Kazuyo
Higashiyama, Aya
Kadota, Aya
Sugiyama, Daisuke
Miyamatsu, Naomi
Miyamoto, Yoshihiro
Okamura, Tomonori
author_sort Hattori, Hiroko
collection PubMed
description The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
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spelling pubmed-74596302020-09-02 Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents Hattori, Hiroko Hirata, Aya Kubo, Sachimi Nishida, Yoko Nozawa, Miki Kawamura, Kuniko Hirata, Takumi Kubota, Yoshimi Sata, Mizuki Kuwabara, Kazuyo Higashiyama, Aya Kadota, Aya Sugiyama, Daisuke Miyamatsu, Naomi Miyamoto, Yoshihiro Okamura, Tomonori Int J Environ Res Public Health Article The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage. MDPI 2020-08-11 2020-08 /pmc/articles/PMC7459630/ /pubmed/32796692 http://dx.doi.org/10.3390/ijerph17165811 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hattori, Hiroko
Hirata, Aya
Kubo, Sachimi
Nishida, Yoko
Nozawa, Miki
Kawamura, Kuniko
Hirata, Takumi
Kubota, Yoshimi
Sata, Mizuki
Kuwabara, Kazuyo
Higashiyama, Aya
Kadota, Aya
Sugiyama, Daisuke
Miyamatsu, Naomi
Miyamoto, Yoshihiro
Okamura, Tomonori
Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title_full Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title_fullStr Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title_full_unstemmed Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title_short Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents
title_sort estimated 24 h urinary sodium-to-potassium ratio is related to renal function decline: a 6-year cohort study of japanese urban residents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459630/
https://www.ncbi.nlm.nih.gov/pubmed/32796692
http://dx.doi.org/10.3390/ijerph17165811
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