Cargando…

Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients

This study is intended to explore the associations between nutritional status and molecular biomarkers and the clinical severity of Parkinson’s disease (PD), as well as to examine the differences in related factors between PD patients with normal nutrition and those with at risk for malnutrition. A...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Tsu-Kung, Chang, Yung-Yee, Chen, Nai-Ching, Liou, Chia-Wei, Lan, Min-Yu, Chen, Ying-Fa, Tsai, Chia-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459923/
https://www.ncbi.nlm.nih.gov/pubmed/32784774
http://dx.doi.org/10.3390/ijerph17165727
_version_ 1783576482399911936
author Lin, Tsu-Kung
Chang, Yung-Yee
Chen, Nai-Ching
Liou, Chia-Wei
Lan, Min-Yu
Chen, Ying-Fa
Tsai, Chia-Liang
author_facet Lin, Tsu-Kung
Chang, Yung-Yee
Chen, Nai-Ching
Liou, Chia-Wei
Lan, Min-Yu
Chen, Ying-Fa
Tsai, Chia-Liang
author_sort Lin, Tsu-Kung
collection PubMed
description This study is intended to explore the associations between nutritional status and molecular biomarkers and the clinical severity of Parkinson’s disease (PD), as well as to examine the differences in related factors between PD patients with normal nutrition and those with at risk for malnutrition. A cross-sectional assessment of 82 consecutive outpatients with PD was conducted using the mini nutritional assessment (MNA), Unified Parkinson’s Disease Rating Scale (UPDRS), and the Hoehn and Yahr scale to determine the nutritional status, the clinical severity of PD, and the stage of the disease. Recordings of blood samples collected after 12 h of overnight fasting were also assessed in terms of serum levels of glycated hemoglobin (HbA1c), blood urea nitrogen (BUN), creatinine, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), hemoglobin (Hgb), folate, and vitamin B12. All participants were divided into normal nutrition and malnutrition risk groups via the MNA scores to compare the above-mentioned parameters. The results showed that the total MNA score was significantly correlated with some parts of the UPDRS scale (e.g., Sections 1 and 2) and the levels of HbAlc in PD patients and those with risk for malnutrition, with significantly lower weight and body mass index (BMI), and with lower levels of Hgb and HDL. Higher levels of cholesterol were observed in the malnutrition risk group as compared with the normal nutrition group. The findings suggest that the clinical severity of PD is associated with nutritional status. Body weight, BMI, and the levels of Hgb, cholesterol, and HDL could be, at least partially, important biological markers to monitor malnutrition and the progression of the disease.
format Online
Article
Text
id pubmed-7459923
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74599232020-09-02 Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients Lin, Tsu-Kung Chang, Yung-Yee Chen, Nai-Ching Liou, Chia-Wei Lan, Min-Yu Chen, Ying-Fa Tsai, Chia-Liang Int J Environ Res Public Health Article This study is intended to explore the associations between nutritional status and molecular biomarkers and the clinical severity of Parkinson’s disease (PD), as well as to examine the differences in related factors between PD patients with normal nutrition and those with at risk for malnutrition. A cross-sectional assessment of 82 consecutive outpatients with PD was conducted using the mini nutritional assessment (MNA), Unified Parkinson’s Disease Rating Scale (UPDRS), and the Hoehn and Yahr scale to determine the nutritional status, the clinical severity of PD, and the stage of the disease. Recordings of blood samples collected after 12 h of overnight fasting were also assessed in terms of serum levels of glycated hemoglobin (HbA1c), blood urea nitrogen (BUN), creatinine, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), hemoglobin (Hgb), folate, and vitamin B12. All participants were divided into normal nutrition and malnutrition risk groups via the MNA scores to compare the above-mentioned parameters. The results showed that the total MNA score was significantly correlated with some parts of the UPDRS scale (e.g., Sections 1 and 2) and the levels of HbAlc in PD patients and those with risk for malnutrition, with significantly lower weight and body mass index (BMI), and with lower levels of Hgb and HDL. Higher levels of cholesterol were observed in the malnutrition risk group as compared with the normal nutrition group. The findings suggest that the clinical severity of PD is associated with nutritional status. Body weight, BMI, and the levels of Hgb, cholesterol, and HDL could be, at least partially, important biological markers to monitor malnutrition and the progression of the disease. MDPI 2020-08-07 2020-08 /pmc/articles/PMC7459923/ /pubmed/32784774 http://dx.doi.org/10.3390/ijerph17165727 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Tsu-Kung
Chang, Yung-Yee
Chen, Nai-Ching
Liou, Chia-Wei
Lan, Min-Yu
Chen, Ying-Fa
Tsai, Chia-Liang
Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title_full Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title_fullStr Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title_full_unstemmed Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title_short Nutritional Status Associated with Molecular Biomarkers, Physiological Indices, and Clinical Severity in Parkinson’s Disease Patients
title_sort nutritional status associated with molecular biomarkers, physiological indices, and clinical severity in parkinson’s disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459923/
https://www.ncbi.nlm.nih.gov/pubmed/32784774
http://dx.doi.org/10.3390/ijerph17165727
work_keys_str_mv AT lintsukung nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT changyungyee nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT chennaiching nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT liouchiawei nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT lanminyu nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT chenyingfa nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients
AT tsaichialiang nutritionalstatusassociatedwithmolecularbiomarkersphysiologicalindicesandclinicalseverityinparkinsonsdiseasepatients