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Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity

Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of th...

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Autores principales: Vinciguerra, Federica, Tumminia, Andrea, Baratta, Roberto, Ferro, Alfredo, Alaimo, Salvatore, Hagnäs, Maria, Graziano, Marco, Vigneri, Riccardo, Frittitta, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459932/
https://www.ncbi.nlm.nih.gov/pubmed/32731619
http://dx.doi.org/10.3390/life10080127
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author Vinciguerra, Federica
Tumminia, Andrea
Baratta, Roberto
Ferro, Alfredo
Alaimo, Salvatore
Hagnäs, Maria
Graziano, Marco
Vigneri, Riccardo
Frittitta, Lucia
author_facet Vinciguerra, Federica
Tumminia, Andrea
Baratta, Roberto
Ferro, Alfredo
Alaimo, Salvatore
Hagnäs, Maria
Graziano, Marco
Vigneri, Riccardo
Frittitta, Lucia
author_sort Vinciguerra, Federica
collection PubMed
description Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype.
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spelling pubmed-74599322020-09-02 Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity Vinciguerra, Federica Tumminia, Andrea Baratta, Roberto Ferro, Alfredo Alaimo, Salvatore Hagnäs, Maria Graziano, Marco Vigneri, Riccardo Frittitta, Lucia Life (Basel) Article Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype. MDPI 2020-07-28 /pmc/articles/PMC7459932/ /pubmed/32731619 http://dx.doi.org/10.3390/life10080127 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vinciguerra, Federica
Tumminia, Andrea
Baratta, Roberto
Ferro, Alfredo
Alaimo, Salvatore
Hagnäs, Maria
Graziano, Marco
Vigneri, Riccardo
Frittitta, Lucia
Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title_full Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title_fullStr Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title_full_unstemmed Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title_short Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
title_sort prevalence and clinical characteristics of children and adolescents with metabolically healthy obesity: role of insulin sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459932/
https://www.ncbi.nlm.nih.gov/pubmed/32731619
http://dx.doi.org/10.3390/life10080127
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