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First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was...

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Autores principales: Zou, Zhijun, Liu, Wei, Huang, Chen, Sun, Chanjuan, Zhang, Jialing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460111/
https://www.ncbi.nlm.nih.gov/pubmed/32784540
http://dx.doi.org/10.3390/ijerph17165700
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author Zou, Zhijun
Liu, Wei
Huang, Chen
Sun, Chanjuan
Zhang, Jialing
author_facet Zou, Zhijun
Liu, Wei
Huang, Chen
Sun, Chanjuan
Zhang, Jialing
author_sort Zou, Zhijun
collection PubMed
description Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was conducted among preschoolers in Shanghai, China during 2011–2012. A questionnaire regarding household environment and lifestyles and childhood health outcomes was reported by the child’s parents. Results: In total, 13,335 questionnaires (response rate: 85.3%) were analyzed and 3049 (24.1%) children had first-year antibiotics exposure. In the multivariate logistic regression analyses, first-year antibiotics exposure had significant associations with the higher odds of lifetime-ever pneumonia (adjusted OR, 95% CI: 2.15, 1.95–2.37), croup (1.46, 1.24–1.73), wheeze (1.44, 1.30–1.60), asthma (1.38, 1.19–1.61), food allergy (1.29, 1.13–1.46), and allergic rhinitis (1.23, 1.07–1.41), and as well as current (one year before the survey) common cold (≥3 times) (1.38, 1.25–1.52), dry cough (1.27, 1.13–1.42), atopic dermatitis (1.25, 1.09–1.43), wheeze (1.23, 1.10–1.38), and rhinitis symptoms (1.15, 1.04–1.26). These associations were different in children with different individual characteristics (age, sex, family history of atopy, and district) and other early exposures (breastfeeding, home decoration, pet-keeping, and environmental tobacco smoke). Conclusions: Our results indicate that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms. The individual characteristics and other early exposures may modify effects of early antibiotic exposure on childhood allergies and airway illnesses.
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spelling pubmed-74601112020-09-02 First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses Zou, Zhijun Liu, Wei Huang, Chen Sun, Chanjuan Zhang, Jialing Int J Environ Res Public Health Article Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was conducted among preschoolers in Shanghai, China during 2011–2012. A questionnaire regarding household environment and lifestyles and childhood health outcomes was reported by the child’s parents. Results: In total, 13,335 questionnaires (response rate: 85.3%) were analyzed and 3049 (24.1%) children had first-year antibiotics exposure. In the multivariate logistic regression analyses, first-year antibiotics exposure had significant associations with the higher odds of lifetime-ever pneumonia (adjusted OR, 95% CI: 2.15, 1.95–2.37), croup (1.46, 1.24–1.73), wheeze (1.44, 1.30–1.60), asthma (1.38, 1.19–1.61), food allergy (1.29, 1.13–1.46), and allergic rhinitis (1.23, 1.07–1.41), and as well as current (one year before the survey) common cold (≥3 times) (1.38, 1.25–1.52), dry cough (1.27, 1.13–1.42), atopic dermatitis (1.25, 1.09–1.43), wheeze (1.23, 1.10–1.38), and rhinitis symptoms (1.15, 1.04–1.26). These associations were different in children with different individual characteristics (age, sex, family history of atopy, and district) and other early exposures (breastfeeding, home decoration, pet-keeping, and environmental tobacco smoke). Conclusions: Our results indicate that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms. The individual characteristics and other early exposures may modify effects of early antibiotic exposure on childhood allergies and airway illnesses. MDPI 2020-08-07 2020-08 /pmc/articles/PMC7460111/ /pubmed/32784540 http://dx.doi.org/10.3390/ijerph17165700 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zou, Zhijun
Liu, Wei
Huang, Chen
Sun, Chanjuan
Zhang, Jialing
First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title_full First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title_fullStr First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title_full_unstemmed First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title_short First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
title_sort first-year antibiotics exposure in relation to childhood asthma, allergies, and airway illnesses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460111/
https://www.ncbi.nlm.nih.gov/pubmed/32784540
http://dx.doi.org/10.3390/ijerph17165700
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