Exploration of the Electrophilic Reactivity of the Cytotoxic Marine Alkaloid Discorhabdin C and Subsequent Discovery of a New Dimeric C-1/N-13-Linked Discorhabdin Natural Product

The cytotoxic marine natural product discorhabdin C contains a 2,6-dibromo-cyclohexa-2,5-diene moiety, previously proposed to be a critical feature required for biological activity. We have determined that the dienone-ring of discorhabdin C is indeed electrophilic, reacting with thiol and amine nucl...

Descripción completa

Detalles Bibliográficos
Autores principales: Lam, Cary F. C., Cadelis, Melissa M., Copp, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460216/
https://www.ncbi.nlm.nih.gov/pubmed/32752009
http://dx.doi.org/10.3390/md18080404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460216/
https://www.ncbi.nlm.nih.gov/pubmed/32752009
http://dx.doi.org/10.3390/md18080404

Ejemplares similares