Cargando…

Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature

The presence of endometriosis determines an inflammatory response locally. The objective of this validation study and systematic review was to assess systemic levels of coagulation and inflammatory parameters in women with or without the disease. We conducted a retrospective analysis of a database p...

Descripción completa

Detalles Bibliográficos
Autores principales: Ottolina, Jessica, Bartiromo, Ludovica, Dolci, Carolina, Salmeri, Noemi, Schimberni, Matteo, Villanacci, Roberta, Viganò, Paola, Candiani, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460223/
https://www.ncbi.nlm.nih.gov/pubmed/32784640
http://dx.doi.org/10.3390/diagnostics10080567
_version_ 1783576552453177344
author Ottolina, Jessica
Bartiromo, Ludovica
Dolci, Carolina
Salmeri, Noemi
Schimberni, Matteo
Villanacci, Roberta
Viganò, Paola
Candiani, Massimo
author_facet Ottolina, Jessica
Bartiromo, Ludovica
Dolci, Carolina
Salmeri, Noemi
Schimberni, Matteo
Villanacci, Roberta
Viganò, Paola
Candiani, Massimo
author_sort Ottolina, Jessica
collection PubMed
description The presence of endometriosis determines an inflammatory response locally. The objective of this validation study and systematic review was to assess systemic levels of coagulation and inflammatory parameters in women with or without the disease. We conducted a retrospective analysis of a database prospectively collected from January 2017 to February 2020 including n = 572 women who underwent laparoscopic surgery for endometriosis (cases, n = 324) or other benign gynecologic diseases (controls, n = 248). Inflammatory markers and coagulation parameters were determined. An advanced systematic search of the literature on the same parameters was conducted up to April 2020. A significantly higher neutrophil count was found in endometriosis patients. Patients with endometriomas and stage III–IV disease had a significantly lower absolute lymphocyte count and shortened activated partial thromboplastin time (aPTT) values. In the final regression model, aPTT retained significant predictive value for stage III–IV endometriosis (odds ratio (OR) = 0.002, 95% confidence interval (CI) = 0.00–0.445; p = 0.024). Results from the n = 14 included studies in the systematic review are characterized by a high variability, but some consistency has been found for alterations in thrombin time, platelet-to-lymphocyte ratio, and neutrophil count associated with endometriosis. Modest systemic changes of some inflammatory and coagulation parameters are associated with endometriosis. Indeed, all the modifications detected are still within the normal reference intervals, explaining the high heterogeneity among studies.
format Online
Article
Text
id pubmed-7460223
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74602232020-09-02 Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature Ottolina, Jessica Bartiromo, Ludovica Dolci, Carolina Salmeri, Noemi Schimberni, Matteo Villanacci, Roberta Viganò, Paola Candiani, Massimo Diagnostics (Basel) Article The presence of endometriosis determines an inflammatory response locally. The objective of this validation study and systematic review was to assess systemic levels of coagulation and inflammatory parameters in women with or without the disease. We conducted a retrospective analysis of a database prospectively collected from January 2017 to February 2020 including n = 572 women who underwent laparoscopic surgery for endometriosis (cases, n = 324) or other benign gynecologic diseases (controls, n = 248). Inflammatory markers and coagulation parameters were determined. An advanced systematic search of the literature on the same parameters was conducted up to April 2020. A significantly higher neutrophil count was found in endometriosis patients. Patients with endometriomas and stage III–IV disease had a significantly lower absolute lymphocyte count and shortened activated partial thromboplastin time (aPTT) values. In the final regression model, aPTT retained significant predictive value for stage III–IV endometriosis (odds ratio (OR) = 0.002, 95% confidence interval (CI) = 0.00–0.445; p = 0.024). Results from the n = 14 included studies in the systematic review are characterized by a high variability, but some consistency has been found for alterations in thrombin time, platelet-to-lymphocyte ratio, and neutrophil count associated with endometriosis. Modest systemic changes of some inflammatory and coagulation parameters are associated with endometriosis. Indeed, all the modifications detected are still within the normal reference intervals, explaining the high heterogeneity among studies. MDPI 2020-08-07 /pmc/articles/PMC7460223/ /pubmed/32784640 http://dx.doi.org/10.3390/diagnostics10080567 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ottolina, Jessica
Bartiromo, Ludovica
Dolci, Carolina
Salmeri, Noemi
Schimberni, Matteo
Villanacci, Roberta
Viganò, Paola
Candiani, Massimo
Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title_full Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title_fullStr Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title_full_unstemmed Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title_short Assessment of Coagulation Parameters in Women Affected by Endometriosis: Validation Study and Systematic Review of the Literature
title_sort assessment of coagulation parameters in women affected by endometriosis: validation study and systematic review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460223/
https://www.ncbi.nlm.nih.gov/pubmed/32784640
http://dx.doi.org/10.3390/diagnostics10080567
work_keys_str_mv AT ottolinajessica assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT bartiromoludovica assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT dolcicarolina assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT salmerinoemi assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT schimbernimatteo assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT villanacciroberta assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT viganopaola assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature
AT candianimassimo assessmentofcoagulationparametersinwomenaffectedbyendometriosisvalidationstudyandsystematicreviewoftheliterature