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EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update
We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460255/ https://www.ncbi.nlm.nih.gov/pubmed/32756375 http://dx.doi.org/10.3390/biomedicines8080269 |
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author | Fulgenzi, Alessandro Vietti, Daniele Ferrero, Maria Elena |
author_facet | Fulgenzi, Alessandro Vietti, Daniele Ferrero, Maria Elena |
author_sort | Fulgenzi, Alessandro |
collection | PubMed |
description | We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA(2)EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms. |
format | Online Article Text |
id | pubmed-7460255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74602552020-09-02 EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update Fulgenzi, Alessandro Vietti, Daniele Ferrero, Maria Elena Biomedicines Article We have previously described the role played by toxic-metal burdens in the etiology of neurodegenerative diseases (ND). We herein report an updated evaluation of toxic-metal burdens in human subjects affected or not affected by ND or other chronic diseases. Each subject underwent a chelation test with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNA(2)EDTA or EDTA) to identify the presence of 20 toxic metals in urine samples using inductively coupled plasma mass spectrometry. Our results show the constant presence of toxic metals, such as lead, cadmium, cesium, and aluminum, in all examined subjects but the absence of beryllium and tellurium. Gadolinium was detected in patients undergoing diagnostic magnetic resonance imaging. The presence of toxic metals was always significantly more elevated in ND patients than in healthy controls. Treatment with EDTA chelation therapy removes toxic-metal burdens and improves patient symptoms. MDPI 2020-08-03 /pmc/articles/PMC7460255/ /pubmed/32756375 http://dx.doi.org/10.3390/biomedicines8080269 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fulgenzi, Alessandro Vietti, Daniele Ferrero, Maria Elena EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title | EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title_full | EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title_fullStr | EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title_full_unstemmed | EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title_short | EDTA Chelation Therapy in the Treatment of Neurodegenerative Diseases: An Update |
title_sort | edta chelation therapy in the treatment of neurodegenerative diseases: an update |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460255/ https://www.ncbi.nlm.nih.gov/pubmed/32756375 http://dx.doi.org/10.3390/biomedicines8080269 |
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